Total Synthesis and Chemistry of Natural Products

This Collection supports and amplifies research related to SDG 3 Ensure healthy lives and promote well-being for all at all ages.

Total synthesis and natural product chemistry enable the creation of complex, stereochemically defined molecules, driving advances in retrosynthetic strategy, reaction discovery, and molecular design. These efforts also provide access to scarce natural products and functional analogues, connecting synthetic innovation to biology and medicine.

With this cross-journal Collection, the editors at Nature Communications, Communications Chemistry, and Scientific Reports invite manuscripts on total synthesis, including innovative methodology, retrosynthetic design, bioinspired strategies, AI-assisted retrosynthesis, and emerging technologies such as automation and high-throughput experimentation; as well as natural product discovery and diversification. Nature Communications and Communications Chemistry will consider Articles, Reviews, and Perspectives, while Scientific Reports will consider Articles.