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Diverse sensory and cognitive functions rely on complex and dynamic neural interactions between cortical and subcortical brain areas to coordinate incoming inputs and feedback processes, creating cortical-subcortical loops. Although these neural networks are believed to support the ability of the mammalian brains to produce adequate behavioral responses in changing environments, their investigation has been limited by technological constraints. Thanks to the recent development of novel genetic tools and technical advances in high density electrophysiology and brain-wide imaging, scientists can now visualize and manipulate the activity of both cortical and subcortical projections, offering novel research perspectives on sensory processing, perception and cognition.
In this Collection, the editors at Communications Biology, Nature Neuroscience, Nature Communications and Scientific Reports welcome original research Articles presenting novel insights into structural and functional cortical-subcortical interactions across sensory modalities and cognitive functions, in humans and animal models, under physiological or pathological conditions. This call for papers includes but is not limited to studies presenting novel cortical-subcortical circuit mechanisms underlying adaptive sensing, perception, attention, decision-making, learning & memory, and language. We also encourage submissions that showcase novel innovative tools and computational models to explore the biology of cortical-subcortical brain loops.