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Cognition - preclinical models, and preclinical unmet need

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Open
Submission deadline

Cognitive impairment is prevalent across the PD trajectory from PD-MCI to dementia and is now even defined with standardized Movement Disorder Society (MDS) criteria for more rigorous phenotyping and trial design. We particularly request mechanistic and biomarker-driven studies that clarify how neural systems support (or fail to support) cognitive abilities, including studies leveraging multimodal neuroimaging, genetics, or computational modeling.

The focus of the issue will be:

  1. Translational work quantifying cognitive outcomes and test therapeutic strategies 
  2. Neuromodulatory approaches for therapeutic strategies and its impact on Cognition
  3. Digital/closed-loop approaches alongside innovative digital biomarkers from wearables and smartphones for real-world assessment of cognition. 
  4. Methodological advancement in clinical and or behavioral assessments of cognitive functions
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