Intracellular organelles in cancer

This Collection supports and amplifies research related to SDG 3 - Ensure healthy lives and promote well-being for all at all ages.

Intracellular organelles play pivotal roles in the maintenance of cellular homeostasis. As our understanding of tumorigenesis deepens, it has become increasingly clear that the functionality and interactions of organelles—such as mitochondria, lysosomes, endosomes, and the endoplasmic reticulum—are intimately linked to cancer formation, progression, and therapy response. The emergence of membraneless organelles, like stress granules and processing bodies, adds on to this intricate web of intracellular communications, suggesting that the organelle interactome is a critical player in the pathogenesis of cancer, as well as a promising target for therapeutic intervention.

With this cross-journal Collection, the editors at Nature Communications, Communications Biology and Scientific Reports invite submissions aiming to explore the intricate roles of intracellular organelles and their interactions in cancer cells or cellular components in the tumor microenvironment. We would also highlight studies reporting technological advances in probing organelle dynamics in cancer, and developing targeted therapies that have translational potential.