Perspectives in 2025

The ancestral evolutionary states of thylakoid membranes may have been initially dedicated to non-oxygenic alternative electron flows.

Motion sickness, a common response to unnatural motion, varies widely among individuals. A review of recent findings highlights the gut’s active role, including its brain-body pathways potentially driving pathophysiology and hinting at a more complex model than previously thought.

This Perspective presents a JEVbased gene therapy platform that delivers and amplifies RNA ASOs within neurons to silence mutant SOD1 in ALS. By combining Trojan horse delivery, neuronspecific replication, and sustained action, this strategy offers a precise and durable framework for CNS-targeted intervention.

This Perspective article proposes a neurodynamical model of intuition as a fast, embodied pathfinding mechanism shaped by evolution. Drawing on the free-energy principle and metastability, it explores how the brain predicts, feels, and acts through dynamic coordination.

Palaeo-bioinspiration greatly increases the potential of nature-inspired innovation by incorporating extinct biodiversity, which represents 99.9% of all life on earth.

This perspective highlights spatially restricted coral bleaching as an underexplored ecological phenomenon that offers critical insight into within-colony heterogeneity.

Archaeal research and its growing importance have benefited from a community that is engaged in various collaborative efforts, which are highlighted here with examples for the sharing of resources and data, as well as the building of supportive environments to advance the community.

Removal of sharks and large teleosts by fishing creates a trophic cascade by altering anti-predator behaviors of mesopredatory fishes, which reduces predation on Crown of Thorns Starfish, allowing the species to form outbreaks on coral reefs.