Articles in 2024

This study shows that using gene-editing technology in oocytes using Platinum TALEN is an effective method for producing genetically modified marmosets by exon skipping.

This Review provides a comprehensive overview of several available animal models of sudden unexpected death in epilepsy (SUDEP), highlighting their pros and cons to elucidate SUDEP causes and mechanisms.

The Laboratory Animal Genetic Reporting (LAG-R) framework, developed by a team of international experts, was recently published in Nature Communications. The LAG-R framework proposes a collection of guidelines to improve the reporting of genetic information for animal models. Lab Animal spoke with corresponding authors Lydia Teboul and Guillaume Pavlovic to know more about the motivation for these recommendations, the benefits for researchers and how to accelerate their adoption.

A highly pathogenic H5N1 influenza virus is spreading in U.S. dairy cattle and has been transmitted to other species, including humans, probably through contaminated milk. Understanding how the virus spreads among cattle and its potential for mammalian adaptation and airborne transmission is crucial for effective outbreak control and public health safety.

Free flap is widely used in head and neck reconstructive surgery, but fluid management of surgical patients remains controversial. Here, Thiem et al. used a pig model to monitor the effects of volume management on free flap perfusion and metabolism.