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Volume 54 Issue 9, September 2025

Progressive meta-inflammation in obese pigs

Chronic low-grade inflammation, which is a common condition in obesity, has been associated with metabolic and cardiovascular dysfunction. In a new Article, Starbæk et al. show that Göttingen minipigs fed a high-fat, fructose and cholesterol diet develop meta-inflammation and endotoxemia. This study offers a valuable model for better understanding the link between obesity, meta-inflammation and cardiometabolic diseases.

See Starbæk et al

Cover image: ChrisGorgio/iStock/Getty and Marina Spence. Cover design: Marina Spence

Volume 54 Issue 9

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  • The study of aging and age-related diseases has traditionally focused on short-lived laboratory species such as mice. The common degu (Octodon degus) is a long-lived rodent species native to Chile that naturally develops neuropathology and behavioral deficits characteristic of Alzheimer’s disease together with other comorbidities associated with aging. These characteristics make the degu a useful model to gain insights into the interaction of aging and neurodegeneration.

    • Michael J. Hurley
    • B. Maximiliano Garduño
    • Patricia Cogram
    Comment Open Access

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