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Subcellular quantitative analysis has been a long-standing goal of mass spectrometry imaging, but was originally thought to be unattainable. However, recent advances have made organelle-level absolute quantification through mass spectrometry imaging a reality, thanks to the development of nano secondary ion mass spectrometry.
Spatial metabolomics has matured and is driving innovation in mass spectrometry, metabolomics and spatial omics. With exciting discoveries, complementary capabilities and increasing accessibility, it has secured its place in the spatial biology toolbox, showing promise in biology, medicine and pharmacology.
Growing evidence demonstrates the metabolic benefits of repeated cold exposure in humans. Here, we argue that skeletal muscle thermogenesis, rather than the stimulation of thermogenic adipose tissue, is required to elicit these benefits in humans.
The metabolomics literature suffers from ambiguity in the nomenclature for individual metabolites, which introduces a disconnect between publications and leads to misinterpretations. This Comment proposes recommendations for metabolite annotations to engage the scientific community and publishers to adopt a more consistent approach to metabolite nomenclature.
The environment experienced by an individual early in life has long-term health consequences. Here we summarize key factors that should be considered when designing studies in rodents that aim to address the developmental programming of metabolic disease.
