Articles in 2013

The use of coiled coils could facilitate the modular, predictable design of protein nanocages.

Four independent studies shed light on the specificity of RNA-guided genome editing tools based on the Streptococcus pyogenes Cas9 protein.

Viral vectors that elicit CD8 T-cell responses of unprecedented breadth and promiscuity may aid the design of improved HIV vaccines.

A shift away from hiring narrowly focused specialists to individuals with interdisciplinary academic training highlights the latest life sciences workforce trends.

Despite recent failures, a flurry of activity in biotech and pharma is raising hopes that an effective drug for this fatal lung disease is on the way. Ken Garber investigates.

Disputes over how to assess a foodstuff's safety continue to play into public fears about transgenic crops.

Pulse-like expression of VEGF-A from modified RNA extends survival in a mouse model of myocardial infarction.

The engineering of biomimetic materials is accelerated by combining high-throughput RNA sequencing and proteomics.

The functional composition of microbial community samples from several environments is predicted based on 16S ribosomal RNA gene sequencing data.

TALENs expressed in somatic cells under the control of tissue-specific or inducible promoters generate conditional knockouts in C. elegans.

Engineering motif-specific 'hot spots' into an antibody scaffold yields antibodies with high affinity to targets containing phosphoserine, phosphothreonine or phosphotyrosine.

A strategy exploiting species-specific miRNA expression may provide another layer of biosafety in gain-of-function influenza experiments.