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Volume 26 Issue 6, June 2008

A Nomarski image of a live zebrafish embryo at 16.5 hours post-fertilization. The rainbow effect was created by slightly pulling out the differential interference contrast slider. Meng et al. and Doyon et al. demonstrate targeted genetic modification of the zebrafish germ line using zinc-finger nucleases. (pp 695 and 702) Credit: Sharon L. Amacher

Volume 26 Issue 6

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  • The heparin scare highlights the need not only for more effective systems of adverse event reporting and product tracking, but also for drug makers to tighten scrutiny of their suppliers.

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  • Despite tightened legislation against animal rights extremism, activists are increasing attacks on academics and researchers in big pharma. How much of a threat do they pose to researchers working in biotech? Brady Huggett investigates.

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  • The discovery of a contaminant in batches of heparin throws into stark relief the difficulties, not only for the US Food and Drug Administration, but also for international regulatory agencies, to ensure the safety and quality of active pharmaceutical ingredients.

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    • Lakshmi Nair
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  • The heparin safety crisis sends a strong signal that urgent changes in regulatory and manufacturing oversight are needed to ensure the safety of the global drug supply.

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  • Directed gene knockout in a vertebrate has been achieved using zinc-finger nucleases.

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  • Mass spectrometry analysis of proteome-derived peptide libraries enables high-throughput determination of protease substrate specificity.

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  • Analysis of the transgenic papaya genome sequence suggests that transgenes generally stay put following integration and can achieve stable expression level from generation to generation.

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  • A regulator of the spatial organization of chromatin may be a promising target to curb the invasiveness of breast cancer.

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  • Technology transfer professionals work at the interface of science and business to help move discoveries forward for the public good.

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