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This Perspective presents recent insights into vimentin filament structure and function and discusses emerging findings that point to a role in tumour invasion in mesenchymal cells analogous to embryonic development and wound healing.
This Perspective discusses the emerging cellular roles of lysine lactylation, with a focus on the lactyl-CoA-independent pathway, and highlights the potential strategies of targeting lactylation for the treatment of associated human diseases.
This Perspective discusses the various biases that can emerge along the pipeline of machine learning-based single-cell analysis and presents methods to train models on human single-cell data in order to assess and mitigate these biases.
