Articles in 2015

Forming a dipole layer at the electron-collecting interface is a proposed method of efficiency enhancement in solar cells. Here, Nam et al.report the use of PEOz as a dipole layer, which increases the work function at the electron-collecting interface within the polymer solar cell leading to an efficiency of 10.7%.

Pertussis toxin is used extensively for perturbing Gαi/o pathways in the study of physiology and disease, but an equivalent inhibitor of Gαq signalling is not currently available to the research community. Here the authors characterize FR900359 as a specific Gq inhibitor and demonstrate its utility to dissect GPCR signalling and its potential to inhibit melanoma cells.

Down syndrome is associated with both central and peripheral nervous system dysfunction. Here, the authors report reduced sympathetic neural innervation in human Down syndrome tissues and a mouse model, and propose a role for RCAN1 trisomy in disrupted NGF receptor trafficking and neurotrophic support.

Oxide materials that undergo a metal to insulator transition under an applied electric field could extend the functionality of electronic devices. Here, the authors induce a phase transition in vanadium dioxide via a titanium dioxide gate, and thus modulate the current flowing through the channel.

In value-based decisions, the longer one fixates on an option, the more likely one is to choose it. Here, the authors compare the performance of people with focal frontal lobe damage in a simple choice task and show that damage to the dorsomedial PFC leads to exaggerated fixation-related value updating.

The amygdala in the medial temporal lobe of the human and non-human primate brain is known to process salient social stimuli and to mediate threat discrimination. Here, Dal Monte et al.show that rhesus monkeys with amygdala lesions have deficits in detecting threat signals and directing attention to the eye region of a conspecific's face.

During neural development thalamocortical axons follow corticofugal projections into the neocortex. Here, using a combination of knock down and rescue experiments, the authors show that Draxin expression in neocortical cells promotes thalamic axon projections from the internal capsule.

Dynamics of the Laurasian Seaway are thought to have had wide effects on oceanography and climate in the mid-Mesozoic. Here, the authors show evidence for seawater temperature change, ascribed to tectonic uplift that impeded poleward oceanic heat transport and triggered a cool climate mode in the earliest Middle Jurassic.

Availability of computing power can limit computational analysis of large genetic and genomic datasets. Here, Canela-Xandri, et al. describe a software called DISSECT that is capable of analyzing large-scale genetic data by distributing the work across thousands of networked computers.

Acceptorless dehydrogenation of simple alkanes and alcohols provides useful functionality and typically requires precious metal catalysts. Here, the authors dehydrogenate unactivated alkanes and alcohols at room temperature using earth-abundant metals with hydrogen as the sole by-product.

Phase transformations in nanoparticles can have a large effect on the performance of electrochemical devices and are strongly determined by parameters such as surface energy and faceting. Here, the authors study the hydriding phase transformation in individual palladium nanocubes and uncover individual structure-function relationships.

Slow-dividing ‘loser’ cells are outcompeted by more robust ‘winner’ cells and eliminated by macrophage-like haemocytes in the fruit fly larva. Here the authors show that the dying loser cells secrete the enzyme Tyrosyl-tRNA synthetase that upon Mmp2-mediated cleavage acts as a haemocyte chemoattractant.

Long intervening noncoding RNAs (lincRNAs) are an emerging class of molecular regulators with diverse functions. Here the authors identify Linc-YY1, a novel lincRNA transcribed from the noncoding region of the mouse YY1 gene, that binds to YY1 protein and thereby regulates skeletal muscle differentiation and regeneration.

The mushroom bodies (MBs) in an insect brain integrate and process sensory information. Using fully sequenced/inbred lines of the Drosophila Genetic Reference Panel, this study performs genome wide association analyses and identifies candidate genes affecting MB size, and uses RNAi to functionally validate the identified loci.

Table-top laser-plasma ion accelerators have many potential applications, but achieving simultaneous narrow energy spread and high efficiency remains a challenge. Here, the authors produce ion beams with up to 18 MeV per nucleon whilst keeping the energy spread reduced through a self-organized process.

Chemotherapeutic agents elicit ER and oxidative stress as part of their mode of action. Here the authors show that chemotherapy and ER stress trigger MGST2-based biosynthesis of LTC₄, whose inhibition abolishes chemotherapy- and ER stress-triggered oxidative stress and DNA damage, resulting in the attenuation of cell death.

Triboelectric nanogenerators utilize triboelectrification for harvesting energy from ambient mechanical motions. Here, the authors report an integrated triboelectric nanogenerator system using only human biomechanical energy to generate mW-level DC electricity that is enough to continuously drive various commercial mobile electronics.

Bacterial type III secretion systems (T3SSs) inject virulence effector proteins into eukaryotic cells and are activated by host membrane contact. Here the authors report the in situ structure of the Chlamydia trachomatisT3SS in the presence or absence of host membrane, and observe compaction of the basal body embedded in the bacterial envelope.

Most electrostatic actuators suffer from an operational instability, the so-called pull-in effect. Here, the authors report an electrostatic actuator concept which makes the huge electrostatic forces within nanometre small electrode separation accessible for large deflections.

Neuregulin-1 and DISC1 signalling pathways have both been linked to neurodevelopment and schizophrenia. Here, Seshadri et al. demonstrate that DISC1 negatively regulates NRG1-induced ErbB4 signalling in adult cortical interneurons both in vitro and in vivo, possibly via competitive binding to PSD95.