Registered Report

Studies in mouse models have suggested a link between antibiotic use and breast cancer but epidemiological evidence in human populations is inconsistent. Here, the authors use linked electronic health records from England and Wales to investigate the association between oral antibiotic use and survival in women with breast cancer.

Repeated exposure to misinformation reduces moral condemnation of sharing those falsehoods online. Here, the authors show that this finding replicates and generalizes to new settings and headlines.

Muñoz-Gil and colleagues report the results of an open challenge where they benchmarked algorithms for the characterization of motion changes in single-particle tracking. By ranking methods on simulations, the competition revealed strengths and limitations of AI and classic approaches, guiding researchers toward optimal tools.

The authors conduct a comprehensive assessment of statistical methods for identifying differentially accessible (DA) regions in scATAC-seq data, using a compendium of scATAC-seq experiments paired with bulk ATAC-seq or scRNA-seq from the same cells to evaluate accuracy, bias, robustness, and scalability.

Exploratory behaviours involve a trade-off between exploration and exploitation. Here the authors investigate exploration behaviour across different domains and whether tendency to explore is stable over time.

The authors investigated memory distortions in participants with dysphoria who did not have a diagnosed mental illness. The participants retrieved positive memories with diminished details and emotions, but negative memories with enhanced details and normal or enhanced emotions.

Deciding between known rewarding options and exploring novel avenues is central to decision making. Humans show variability in their exploration. Here, the authors show that impulsivity is associated to an increased usage of a cognitively cheap (and sometimes sub-optimal) exploration strategy.