Review Articles in 2024

This comprehensive review of amygdala intercalated cells (ITCs) proposes a revised model of ITCs as a highly coordinated system that integrates diverse inputs to orchestrate brain-wide networks and shape behavioral states.

This review provides an overview of analysis and experimental design of single-cell omics in the brain, emphasizing epigenomics and spatial omics. The authors discuss how the computational and experimental designs are interlinked, with both being guided by the biological questions.

This Review provides insights for construction of molecular cell atlases and outlines key study design considerations. The authors emphasize the power of single-cell and single-nucleus genomics in revealing cellular transitions during nervous system development and disease.

Single-cell or single-nucleus RNA-sequencing experiments form a basis for biological insights about cell types and states, but they require orthogonal experiments to confirm the functional relevance of their findings. Here the authors discuss options to support such findings and their challenges.

The authors review current knowledge of the molecular identity and functions of the dura, arachnoid and pial layers of meninges and controversial aspects of meningeal biology that deserve further study to resolve ongoing debates in the field.

This Review provides a framework for incorporating APOE into Alzheimer’s disease (AD) clinical care by bridging recent advances in APOE and AD research with emerging clinical applications for APOE testing and ApoE-targeted therapies.

Mature myelin has been considered static, though recent evidence indicates it is in fact dynamic. Here, Osso and Hughes review the dynamics of mature myelin, a form of neuroplasticity, from myelin turnover to remodeling of myelin structure. The authors consider the mechanisms that regulate these dynamics and the functional implications of mature myelin remodeling.