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This Review discusses multiomic approaches for the characterization and biological understanding of cellular senescence, including detailed case studies on skeletal muscle and adipose tissue that highlight current outstanding issues in the field.
This Review discusses noncanonical DNA methylation (mCH) in animal genomes and highlights the remaining need to clarify whether mCH represents a conserved regulatory layer or a lineage-specific epigenetic feature with distinct biological roles.
This Review describes the changes that some organisms make to their own DNA sequences, linking many to common genetic mechanisms built around canonical DNA repair and to a set of functional circumstances that often involve host–pathogen conflicts.
Research is moving from a gene- and protein-centric view toward a holistic understanding of cellular phenotypes. This Review discusses the technological microfluidics challenges that must be addressed to realize integrative single-cell phenomics.
This Review discusses recent advances in circular RNA discovery afforded by breakthroughs in sequencing technologies and deep learning-based algorithms and highlights outstanding challenges in integrating large-scale circular RNA datasets.
Latin America and the Caribbean remain largely underrepresented in psychiatric genetics research. This Review highlights the need for more research in these populations to advance genetic insights and ensure equitable precision medicine access.
This Review discusses the various molecular mechanisms underlying the generation of new genes and highlights their important functions and phenotypes with an emphasis on the evolutionary forces underlying natural selection and sexual conflict.
Long-read sequencing technologies have revolutionized genomics and transcriptomics, and more recently enabled comprehensive epigenomic profiling. These advances now also allow investigation of the relationship between chromatin states and transcriptional dynamics.
Pangenomes integrate multiple genomes to mitigate reference bias. This Review presents tools to build, visualize and manipulate pangenome graphs and also highlights pangenome applications in biodiversity and conservation genomics.
