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Complex digital representations of organs were reconstructed by computationally generating virtual slices from sparsely sampled planar spatial transcriptomic data, exemplified by a 38-million-cell mouse brain atlas that bridges gaps between tissue sections and preserves the continuous three-dimensional (3D) molecular landscape at single-cell resolution.
Since the chance discovery of nanobodies in the late 1980s, their uses and applications have kept growing. Researchers are now exploring new ways to harness nanobody versatility.