Method to Watch

Immune–organoid systems will be the next generation of in vitro models.

CRISPR screens are untangling molecular mechanisms that drive biological processes with greater precision and detail.

Algorithms help to capture macromolecular motion and structural heterogeneity in native cellular environments.

New experimental and computational methods illuminate the history of cell differentiation and its molecular underpinnings.

Experimental and computational studies are paving way for a deeper understanding of the dynamic nature of protein–protein interactions.

Detailed biomechanical models of animal bodies can help to tackle questions about how the brain controls movement and bodily interactions with the environment.

Advances aim to capture comprehensive, dynamic genome structures in living cells.

Advances in multiplexed super-resolution microscopy will usher in the next era of spatial proteomics.

Large language models are learning the language of genomics.

Developments in nanopore-based peptide detection and sequencing show promise of a breakthrough.

Spatially resolved multimodal omics offers a collective way to capture molecular information in complex tissues.

High-resolution connectomics of the human brain is the next frontier in neuroscience.

New twists on established methods and multimodal imaging are poised to bridge gaps between cellular and organismal imaging.

Advances will enable proteome-scale structure determination in cells.

Artificial ECMs enable recapitulation of tissue microenvironments.

Advances in profiling chromosome structure help reveal the regulatory roles of gene organization.

Mechanoimmunology methods help dissect the mechanical forces within the immune system.

CRISPR systems can be leveraged to direct recombinases to integrate gene-sized DNA sequences.

Strategies to overcome poor reproducibility in MRI studies are needed.

In vitro models and single-cell atlases help uncover the mysteries of human embryogenesis.