Method to Watch

Methods to study the structural and functional properties of proteins that contain intrinsically disordered regions at the proteome scale are on the rise.

Protein editors complement genome editing tools by enabling direct modifications to protein molecules.

Extracellular recordings provide a wealth of information about neuronal activity but it is difficult to link this information to cell types.

New technologies and computational approaches will illuminate the role of the cancer microbiome.

Artificial intelligence agents may have a transformative effect on how biological research is performed.

Experimental and computational advances have improved enhancer characterization and design.

Virtual cells based on artificial intelligence models are on the horizon

Predicting the folded structures of RNA molecules poses greater challenges than proteins, but steady progress continues.

Immune–organoid systems will be the next generation of in vitro models.

CRISPR screens are untangling molecular mechanisms that drive biological processes with greater precision and detail.

Algorithms help to capture macromolecular motion and structural heterogeneity in native cellular environments.

New experimental and computational methods illuminate the history of cell differentiation and its molecular underpinnings.

Experimental and computational studies are paving way for a deeper understanding of the dynamic nature of protein–protein interactions.

Detailed biomechanical models of animal bodies can help to tackle questions about how the brain controls movement and bodily interactions with the environment.

Advances aim to capture comprehensive, dynamic genome structures in living cells.

Advances in multiplexed super-resolution microscopy will usher in the next era of spatial proteomics.

Large language models are learning the language of genomics.

Developments in nanopore-based peptide detection and sequencing show promise of a breakthrough.

Spatially resolved multimodal omics offers a collective way to capture molecular information in complex tissues.

High-resolution connectomics of the human brain is the next frontier in neuroscience.