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The FDA-approved antiviral baloxavir improves disease outcomes in mice compared with oseltamivir after ocular and intranasal challenge with A(H5N1)-contaminated cow milk.
An engineered one-carbon-fixation pathway increases biomass yields of Cupriavidus necator compared with the Calvin cycle and can support future, sustainable bio-based production.
Spillover of avian A(H5N1) influenza virus to mammals may favour adaptation to these new hosts. Air sampling of infected ferrets shows that recent A(H5N1) strains, including one from a human case linked to the US cattle outbreak, are efficiently expelled into the air.
The stable integration of a 192 kb plasmid into the chromosome of Clostridium acetobutylicum by a synthetic biology approach enables continuous production of n-butanol.
Comprenhensive analysis of human antibody responses to SARS-CoV-2 variants and animal sarbecoviruses finds that Omicron escapes neutralization more readily than distantly related animal sarbecoviruses.
The closed chromosome of an Asgard archaeon, Candidatus Odinarchaeum yellowstonii LCB_4, revealed CRISPR spacers, which were used to identify archaeal viruses.
The SARS-CoV-2 Lambda variant has been prevalent in Latin America. An analysis of the neutralization capacity of antibodies elicited by CoronaVac and BNT162b2 against SARS-CoV-2 Lambda in plasma from healthcare workers and patients in Chile reveals that BNT162b2 elicits higher neutralizing antibody titres than CoronaVac.
A third vaccination with BNT162b2 against SARS-CoV-2 elicits antibody and T-cell responses in 4 out of 5 reported older adults who were previously low-/non-responders.
The marine bacterium Puniceibacterium antarcticum SM1211 can produce acrylate from dimethylsulfoniopropionate (DMSP) cleavage by the DMSP lyase, DddL, which protects against grazing by a ciliate predator.
The authors characterize two phages against Acinetobacter baumannii, both in vitro and in vivo. A. baumannii strains develop resistance against both phages, but are in turn resensitized to different antimicrobial compounds.
BiofilmQ is an image cytometry software tool that enables the visualization, quantification and analysis of biofilm properties, providing insights into their structure and function.
Electron micrographs show that mouse and rat segmented filamentous bacterium (SFB) unicellular intracellular offspring (IO) are flagellated and that flagellation occurs before IO release from SFB filaments.
Resistance to baloxavir marboxil, a recently approved drug to treat influenza infection, was thought to make the virus less fit. This study reports that resistant viruses isolated from Japanese patients have normal replicative abilities and pathogenicity in animal models and thus might spread in humans.
