Articles

By unifying data from engineered β-barrel nanopores and supported by modelling, it is demonstrated that the lumen charge in a β-barrel nanopore governs rectification and voltage-driven gating, with applications in computing using nanofluidic synapses.

This work presents a degradable ionizable lipid, AMG1541, for mRNA vaccines that significantly enhances potency and enables similar protective immunity at doses 100-fold lower than current standards, while also reducing toxicity and improving clearance in vivo.

Hong–Ou–Mandel experiments on a quantum photonic chip demonstrate on-chip quantum interference of indistinguishable single photons with visibilities exceeding 0.97 for two molecules separately coupled to two waveguides.

Using supramolecular chemistry principles, thermodynamically metastable, yet kinetically stable, poly(disulfide)s with tunable mechanical properties can be recycled into crystalline monomers with quantitative yields and monomer purity >90%.

A gallium-based, iron-embedded liquid metal catalyst enables reversible, magnetic-field-controlled switching between atomically dispersed and clustered iron states, achieving tunable production of CH₃OOH and CH₃COOH under ambient conditions.

A ROS-chemotactic antioxidative nanoscavenger prevents acute thrombosis by protecting vascular endothelial cells from oxidative stress, while circumventing the bleeding risk associated with current clinical antithrombotic drugs.

A miniaturized frequency up-converted electrically tunable single-mode photonic source in the 9.0–10.5 THz range is demonstrated.

The epitaxial growth of hyperdoped Ga:Ge films and trilayer heterostructures by molecular-beam epitaxy yield superconductivity with a critical temperature of 3.5 K and may enable quantum functionalities in this material system, which is accessible with well-established semiconductor technologies.

Formamidinium lead iodide perovskite films exhibit picosecond-scale quantum transients (~2 ps), with their nanoscale superlattices defining energy levels that yield narrow emission lines and reveal the structure–emission relationship.

This study demonstrates how CO₂ directs defect control during the synthesis of Mn-rich sodium layered oxides, improving the stability and performance of earth-abundant positive electrode materials in non-aqueous sodium-based rechargeable batteries.

This study presents a programmable mRNA nanomedicine that induces tumour-specific immunogenic cell death in immunologically cold and metastatic tumours with enhanced safety, advancing next-generation strategies for personalized cancer immunotherapy

Multimodal operando imaging reveals how multiscale structural design affects lithiation heterogeneity and electrochemical cycling stability in graphite/silicon composite battery electrodes.

PEGylated black phosphorus nanosheets boost mitochondrial oxidative phosphorylation, thereby modulating the survival and immune evasion in tumour cells, and further promoting the activation of immune regulation.

Actuators based on DNA–inorganic hybrid crystals reversibly change shape, which can be programmed by the length and composition of the DNA polymer, and induce cascaded reactions of compartmentalized enzymes in response to external stimuli.

In a hybrid superconductor–ferromagnet device, the dynamic stray fields of current-driven vortices unidirectionally excite coherent short-wavelength magnons.

A manually operated portable water disinfection system can rapidly inactivate pathogens in water, offering a promising approach for safe water treatment in low-resource settings.

‘Ultrathin’ gold interlayers are shown to form nanoparticles that balance optical losses and electrical contact, enabling efficient perovskite–perovskite integration for scalable and durable triple-junction photovoltaics.

By carefully dispersing small amounts of Ir into the RuO₂ lattice, a Ru₆IrOₓ catalyst reduces Ir usage by 80% while still running stably for over 1,500 h at 2 A cm⁻² in both laboratory- and industrial-scale proton-exchange membrane water electrolysers.

A spatiotemporally adaptive targeting strategy ensures sequentially reprogramming metabolism of inflammatory macrophages and senescent stem cells via intracellular NAD⁺ replenishment, accelerating bone and skin tissue regeneration.

A hydrogel matrix fabricated by cryo-photocrosslinking enables the direct, scalable isolation of extracellular vesicles from diverse biofluids without preprocessing, allowing for in-gel preservation for long-term storage and biomedical applications.