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Irreversible covalent inhibitors equipped with reporter groups allow the study of target enzymes based on catalytic activity instead of expression level. This Perspective discusses the design and use of such probes directed at the ubiquitin–proteasome system. Can they identify new cancer therapies that target this system?
The Connectivity Map database aims to connect diseases with the genes that cause them and drugs that could treat them. How does this new resource work, and how can it be used by the cancer research community?
