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The vast majority of the research into cancer metabolism has been limited to a handful of metabolic pathways, with other pathways being sidelined. This Progress article brings to light the potential contribution of fatty acid oxidation to cancer cell function.
BAP1 is a deubiquitylase that is associated with multiprotein complexes that regulate key cellular pathways. Recent findings have indicated that germlineBAP1mutations might cause a novel cancer syndrome. Michele Carbone and colleagues discuss the evidence for this.
