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Bile acids are increasingly recognized for their broad metabolic effects, including the regulation of glucose homeostasis. In a recent study published in Nature Metabolism, researchers provide compelling evidence that alteration in bile acid flux — namely, in intestinal absorption and faecal secretion — can directly influence prandial glucose metabolism.
Advances in biomedical research often result from a straightforward formula: a good working hypothesis, a set of dedicated investigators, and access to calorimetric chambers and a laboratory scale. The success of this approach has again been demonstrated in a new Cell Metabolism report showing that tirzepatide induces weight loss through partially distinct mechanisms in mice and humans.
