Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Although most proteins contain multiple domains, nearly all folding studies so far have been of single domains in isolation. Here we consider the importance of interdomain cooperativity in protein folding and propose evolutionary mechanisms that prevent misfolding in multidomain proteins.
