Journal Clubs in 2015

Rong Li tells us about the discovery of the seven-subunit actin nucleator Arp2/3 complex.

M. Bishr Omary reminds us of the three articles that first uncovered a causative link between mutations in intermediate filaments (specifically, keratin 14) and human diseases.

Leonie Ringrose highlights how mathematical modelling can provide insights into fundamental mechanisms underlying epigenetic regulation.

Barry Thompson reminds us how Yorkie was discovered as the transcriptional coactivator downstream of Hippo signalling.

A prophetic theoretical article, which hypothesized that ribosomes have regulatory roles in controlling gene expression, inspired Maria Barna to rethink the value of purely theoretical scientific publications.

Ronald and Joan Conaway highlight studies that established the role of phosphorylation of the RNA polymerase II carboxy-terminal domain (CTD) in the transition from transcription initiation to elongation, which paved the ground for following work on the CTD in regulating co-transcriptional processes.

Robert Grosse discusses how optogenetic strategies have the potential to advance our understanding of protein function and localization in individual living cells.

Stephen J. Royle describes a cutting-edge study that provided definitive evidence for the first time that the kinetochore fibre is a bundle of parallel microtubules.