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Emerging evidence suggests a role for the voltage-gated sodium channel NaV1.9 in pain. In this Progress article, Dib-Hajj, Black and Waxman analyse the findings from three studies that report mutations in the gene encoding NaV1.9 in pain disorders, and suggest that NaV1.9 may be a potential therapeutic target for pain.
Retromer is a protein assembly that has a crucial role in endosomal sorting and trafficking. In this Progress article, Small and Petsko discuss the role of retromer dysfunction in various neurological diseases, including Alzheimer disease and Parkinson disease.
Chemokine receptors and opioid receptors in nociceptive pathways interact in ways that can alter opioid function. In this Progress article, Réaux-Le Goazigo and colleagues discuss how crosstalk between chemokine and opioid receptors offers a new framework for the development of novel analgesic therapies to alleviate pain.
