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In this Perspectives article, Porrini and colleagues appraise the results of studies that have compared the performance of formulae developed to estimate glomerular filtration rate (GFR) against measured GFR reference methods. They contend that the persistence of errors in GFR estimation formulae indicates an inadequacy of serum creatinine and cystatin C levels as markers of actual renal function.
This Perspectives article describes supporting and contradicting data regarding the role of podocyte B7-1 in the pathogenesis of various podocytopathies and highlights issues that need to be addressed to standardize approaches to the study of this protein.
