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The ShangRing is a novel device which has the potential to be used for safe and effective circumcision in areas where good surgical facilities and surgically trained personnel are scarce; and where HIV is widespread. In this Perspectives, the authors discuss the available data on the ShangRing and consider the possibilities for its future use in resource-poor areas.
Each of the kidney cancer genes identified so far interact with cell metabolism pathways involved in energy, nutrient, iron or oxygen sensing. Here, Linehan and colleagues argue that targeting the fundamental cell metabolic abnormalities provides a unique opportunity to develop novel forms of therapy for this disease.
