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Showing 1–50 of 143 results

NEXN protects against vascular calcification by promoting SERCA2 SUMOylation and stabilization

Vascular calcification, a key risk factor of cardiovascular diseases, involves smooth muscle cells shifting to osteogenic phenotype. Here, the authors show that NEXN inhibits this process and protects against calcification by stabilizing SERCA2.

Wenjie Guo
Wenjing Guo
Canzhao Liu
ResearchOpen Access29 Aug 2025
Nature Communications

Volume: 16, P: 1-18
Calcific aortic stenosis

Calcific aortic stenosis (AS) results from the thickening and calcification of valve leaflets and subsequent obstruction of blood-flow across the aortic valve This PrimeView highlights the management of AS, for which the only treatment is aortic valve replacement.

Reviews03 Mar 2016
Nature Reviews Disease Primers

Volume: 2, P: 1
Sex-specific lipidomic signatures in aortic valve disease reflect differential fibro-calcific progression

Fibro-calcific aortic valve disease is closely interlinked with dyslipidemia. Here, the authors used quantitative lipidomics to profile the metabolic trajectories in human aortic valves, and found that male and female patients manifest markedly different lipid signatures of disease progression.

Patricia Prabutzki
Michele Wölk
Maria Fedorova
ResearchOpen Access03 Jun 2025
Nature Communications

Volume: 16, P: 1-16
Contribution of type 2 diabetes to major adverse cardiovascular events (MACE) in a long-term observational study with different stages of atherosclerosis

Arthur Mader
Dario Haeberli
Heinz Drexel
ResearchOpen Access22 Jan 2025
Scientific Reports

Volume: 15, P: 1-9
Impact of provision of abdominal aortic calcification results on fruit and vegetable intake: 12-week randomized phase 2 controlled trial

It is unclear whether providing the results of abdominal aortic calcification imaging to patients improves diet parameters. This randomized trial shows that this intervention does not lead to improvements in fruit and vegetable intake, while showing an effect on some cardiovascular disease risk factors used as secondary outcomes.

Simone Radavelli-Bagatini
Catherine P. Bondonno
Joshua R. Lewis
ResearchOpen Access14 Oct 2024
Nature Communications

Volume: 15, P: 1-11
CCL2-mediated endothelial injury drives cardiac dysfunction in long COVID

Thomas, Noishiki, Gaddam et al. used thrombotic vascular tissues and iPSC-derived cardiac organoids to show that COVID-19-induced endotheliitis and cytokine release disrupt endothelial–cardiomyocyte crosstalk and contribute to cardiac dysfunction in long COVID.

Dilip Thomas
Chikage Noishiki
Nazish Sayed
Research14 Oct 2024
Nature Cardiovascular Research

Volume: 3, P: 1249-1265
Rivaroxaban versus vitamin K antagonist treatment on the progression of coronary calcification: the IRIVASC-trial

Robert Stöhr
Sebastian Reinartz
Vincent Brandenburg
ResearchOpen Access30 Jul 2024
Scientific Reports

Volume: 14, P: 1-7
Endothelial LATS2 is a suppressor of bone marrow fibrosis

Sivaraj, Majev et al. demonstrate that the inactivation of Lats2 in endothelial cells triggers the upregulation of serum response factor and endothelial-to-mesenchymal transition, leading to myofibroblast formation, bone marrow fibrosis, osteosclerosis, impaired bone marrow function and extramedullary hematopoiesis.

Kishor K. Sivaraj
Paul-Georg Majev
Ralf H. Adams
ResearchOpen Access29 Jul 2024
Nature Cardiovascular Research

Volume: 3, P: 951-969
Multi-ancestry genome-wide study identifies effector genes and druggable pathways for coronary artery calcification

Multi-ancestry genome-wide association meta-analysis identifies new risk loci for CAC. Functional evidence implicates candidate causal genes as regulators of smooth muscle cell-mediated calcification.

Maryam Kavousi
Maxime M. Bos
Clint L. Miller
Research28 Sept 2023
Nature Genetics

Volume: 55, P: 1651-1664
Cross-sectional association of equol producing status with aortic calcification in Japanese men aged 40–79 years

Xiao Zhang
Akira Fujiyoshi
Akira Sekikawa
ResearchOpen Access22 Nov 2022
Scientific Reports

Volume: 12, P: 1-8
Smooth muscle NF90 deficiency ameliorates diabetic atherosclerotic calcification in male mice via FBXW7-AGER1-AGEs axis

The accumulation of AGEs is closely related to the atherosclerotic calcification in diabetic patients. Here, the authors find that VSMC NF90 knockout attenuates diabetic atherosclerotic calcification by mediating the metabolic imbalance of AGEs.

Fei Xie
Bin Liu
Ming-xiang Zhang
ResearchOpen Access11 Jun 2024
Nature Communications

Volume: 15, P: 1-17
Association of the trajectory of plasma aldosterone concentration with the risk of cardiovascular disease in patients with hypertension: a cohort study

Xintian Cai
Shuaiwei Song
Nanfang Li
ResearchOpen Access28 Feb 2024
Scientific Reports

Volume: 14, P: 1-8
Aortic calcification correlates with pseudoaneurysm or penetrating aortic ulcer of different etiologies

Siting Li
Haoxuan Kan
Yuehong Zheng
ResearchOpen Access02 Jan 2024
Scientific Reports

Volume: 14, P: 1-9
ENPP1-Fc prevents mortality and vascular calcifications in rodent model of generalized arterial calcification of infancy

Generalized arterial calcification of infancy (GACI) is a terminal disease caused by the ENPP1 enzyme deficiency. Here, Albrigh et al. show that ENPP1 enzyme replacement therapy prevents the ectopic calcifications and mortality in mice with GACI, suggesting a novel treatment for vascular calcification in humans.

Ronald A. Albright
Paul Stabach
Demetrios T. Braddock
ResearchOpen Access01 Dec 2015
Nature Communications

Volume: 6, P: 1-11
Enhancing aortic valve drug delivery with PAR2-targeting magnetic nano-cargoes for calcification alleviation

Achieving targeted drug delivery for calcified aortic valve is challenging. Here, the authors find that protease activated receptor 2 (PAR2) is up-regulated on calcified valves and develop a magnetic nanocarrier functionalized with PAR2-targeting peptide for dual-active drug delivery.

Jinyong Chen
Tanchen Ren
Xianbao Liu
ResearchOpen Access16 Jan 2024
Nature Communications

Volume: 15, P: 1-20
Aged bone matrix-derived extracellular vesicles as a messenger for calcification paradox

This study uncovers the role of extracellular vesicles from bone matrix as a messenger in the development of osteoporosis and vascular calcification (calcification paradox) during skeletal aging and menopause by transferring miR-483-5p and miR-2861.

Zhen-Xing Wang
Zhong-Wei Luo
Hui Xie
ResearchOpen Access18 Mar 2022
Nature Communications

Volume: 13, P: 1-20
Association between the triglyceride-glucose index and calcified aortic stenosis in elderly patients: a cross-sectional study

Zhihui Hu
Tiantian Xiong
Guoming Li
ResearchOpen Access11 Sept 2023
Scientific Reports

Volume: 13, P: 1-8
Changes in intra- and extracranial carotid plaque calcification: a 2-year follow-up study

T. Zadi
D. H. K. van Dam-Nolen
D. Bos
ResearchOpen Access24 May 2023
Scientific Reports

Volume: 13, P: 1-9
Advanced glycation end products accelerate calcification in VSMCs through HIF-1α/PDK4 activation and suppress glucose metabolism

Yi Zhu
Wen-Qi Ma
Nai-Feng Liu
ResearchOpen Access13 Sept 2018
Scientific Reports

Volume: 8, P: 1-12
Correlative light and electron microscopic observation of calcium phosphate particles in a mouse kidney formed under a high-phosphate diet

Batpurev Battulga
Kazuhiro Shiizaki
Nobuhiko Ohno
ResearchOpen Access16 Jan 2023
Scientific Reports

Volume: 13, P: 1-9
Poly(ADP-ribose) polymerase 1 accelerates vascular calcification by upregulating Runx2

Vascular calcification is a hallmark of end stage renal disease. Here, Cheng et al. show that poly(ADP-ribose) polymerase (PARP) activity is increased in calcified arteries in patients and uremic rats, and that PARP1 promotes vascular calcification by suppressing miR-204 expression via IL-6/STAT3 signaling, thus relieving repression of the osteogenic regulator Runx2.

Cheng Wang
Wenjing Xu
Kai Huang
ResearchOpen Access13 Mar 2019
Nature Communications

Volume: 10, P: 1-12
Vascular calcification in different arterial beds in ex vivo ring culture and in vivo rat model

Karen Muyor
Jonas Laget
Nathalie Gayrard
ResearchOpen Access13 Jul 2022
Scientific Reports

Volume: 12, P: 1-10
The nuclear hormone receptor PPARγ counteracts vascular calcification by inhibiting Wnt5a signalling in vascular smooth muscle cells

Vascular calcification is commonly associated with advanced stages of atherosclerosis. Woldtet al. show that the nuclear hormone receptor PPARγ in vascular smooth muscle cells protects mice from vascular calcification by inhibiting Wnt5a signalling triggered by activation of the cell-surface receptor LRP1.

Estelle Woldt
Jérome Terrand
Philippe Boucher
Research25 Sept 2012
Nature Communications

Volume: 3, P: 1-10
Correlative Detection of Isolated Single and Multi-Cellular Calcifications in the Internal Elastic Lamina of Human Coronary Artery Samples

Han Wen
Alejandro Morales Martinez
Ahmed M. Gharib
ResearchOpen Access20 Jul 2018
Scientific Reports

Volume: 8, P: 1-8
AST-120, an Oral Carbon Absorbent, Protects against the Progression of Atherosclerosis in a Mouse Chronic Renal Failure Model by Preserving sFlt-1 Expression Levels

Yasuki Nakada
Kenji Onoue
Yoshihiko Saito
ResearchOpen Access30 Oct 2019
Scientific Reports

Volume: 9, P: 1-7
Coronary artery calcification score in migraine patients

Filipp M. Filippopulos
Florian Schoeberl
Alexander Becker
ResearchOpen Access01 Oct 2019
Scientific Reports

Volume: 9, P: 1-6
Blooming Artifact Reduction in Coronary Artery Calcification by A New De-blooming Algorithm: Initial Study

Ping Li
Lei Xu
Jonathon A. Leipsic
ResearchOpen Access02 May 2018
Scientific Reports

Volume: 8, P: 1-8
Homoarginine/ADMA ratio and homoarginine/SDMA ratio as independent predictors of cardiovascular mortality and cardiovascular events in lower extremity arterial disease

Philipp Jud
Franz Hafner
Gerald Hackl
ResearchOpen Access21 Sept 2018
Scientific Reports

Volume: 8, P: 1-7
Medial artery calcification increases neointimal hyperplasia after balloon injury

Andre P. Marshall
Weifeng Luo
Raul J. Guzman
ResearchOpen Access03 Jun 2019
Scientific Reports

Volume: 9, P: 1-9
The protective effects of renin–angiotensin system componts on vascular calcification

Hui-Yu Bai
Bao-Shuai Shan
Yi-Nong Jiang
Research12 May 2020
Journal of Human Hypertension

Volume: 35, P: 410-418
Association between insulin resistance, hyperglycemia, and coronary artery disease according to the presence of diabetes

Young-Rak Cho
Soe Hee Ann
Sang-Gon Lee
ResearchOpen Access02 Sept 2019
Scientific Reports

Volume: 9, P: 1-7
Impact of acetate- or citrate-acidified bicarbonate dialysate on ex vivo aorta wall calcification

Ricardo Villa-Bellosta
Eduardo Hernández-Martínez
Emilio González-Parra
ResearchOpen Access06 Aug 2019
Scientific Reports

Volume: 9, P: 1-7
Smooth muscle cell-specific deletion of TXNIP ameliorates medial vascular calcification

Ae-Rang Hwang
Chang-Hoon Woo
ResearchOpen Access03 Jul 2025
Experimental & Molecular Medicine

Volume: 57, P: 1519-1535
Evaluating the generalizability of an automated coronary artery calcium segmentation and scoring algorithm using multi-vendor dataset

Doyoung Park
Jedidiah Ng
Lohendran Baskaran
ResearchOpen Access01 Jul 2025
Scientific Reports

Volume: 15, P: 1-12
Step down Vascular Calcification Analysis using State-of-the-Art Nanoanalysis Techniques

Sven C. Curtze
Marita Kratz
Sebastian Vogt
ResearchOpen Access16 Mar 2016
Scientific Reports

Volume: 6, P: 1-9
Circulating microRNAs correlated with the level of coronary artery calcification in symptomatic patients

Wei Liu
Shukuan Ling
Yingxian Li
ResearchOpen Access05 Nov 2015
Scientific Reports

Volume: 5, P: 1-10
The association of serum adiponectin with abdominal aortic calcification in Japanese male hemodialysis patients: a cross-sectional observational study

Takeshi Sakura
Senji Okuno
Masaaki Inaba
ResearchOpen Access25 Jul 2017
Scientific Reports

Volume: 7, P: 1-6
Comparison of the Left Main Coronary Bifurcating Angle among Patients with Normal, Non-significantly and Significantly Stenosed Left Coronary Arteries

Yu-Hsiang Juan
Pei-Kwei Tsay
Yung-Liang Wan
ResearchOpen Access04 May 2017
Scientific Reports

Volume: 7, P: 1-8
Identifying active vascular microcalcification by ¹⁸F-sodium fluoride positron emission tomography

Atherosclerotic plaques with macrocalcification are stable, whereas microcalcification is a key feature of rupture-prone plaques. Here the authors show that¹⁸F-NaF PET/CT imaging can distinguish between macro- and microcalcification providing a potential, non-invasive imaging technique to identify patients with high-risk atheroma.

Agnese Irkle
Alex T. Vesey
Anthony P. Davenport
ResearchOpen Access07 Jul 2015
Nature Communications

Volume: 6, P: 1-11
MDM2 E3 ligase-mediated ubiquitination and degradation of HDAC1 in vascular calcification

Vascular calcification (VC) increases morbidity and mortality in cardiovascular and metabolic diseases. Here, Kwon et al.show that calcification stimuli induce MDM2- mediated ubiquitination and proteasomal degradation of HDAC1, suggesting a possible therapeutic strategy for treatment of VC patients.

Duk-Hwa Kwon
Gwang Hyeon Eom
Hyun Kook
ResearchOpen Access01 Feb 2016
Nature Communications

Volume: 7, P: 1-14
Nano-analytical electron microscopy reveals fundamental insights into human cardiovascular tissue calcification

Analytical techniques reveal that spherical calcium phosphate particles are the first mineralized structures to be formed in the calcification process in cardiovascular tissues. Furthermore, the inner sections of calcified lesions in patients with various cardiovascular diseases are identified as highly crystalline, spherical hydroxyapatite particles that differ in structure from bone mineral.

Sergio Bertazzo
Eileen Gentleman
Molly M. Stevens
Research21 Apr 2013
Nature Materials

Volume: 12, P: 576-583
Inhibition of vascular calcification by inositol phosphates derivatized with ethylene glycol oligomers

Cardiovascular calcification is a serious pathology for which effective pharmacological treatments are lacking. Here the authors show that an optimized oligo(ethylene glycol) derivative of inositol phosphate interferes with calcium phosphate crystallization and inhibits soft tissue calcification in vivo following subcutaneous injection.

Antonia E. Schantl
Anja Verhulst
Jean-Christophe Leroux
ResearchOpen Access05 Feb 2020
Nature Communications

Volume: 11, P: 1-17
ABCC6 deficiency promotes dyslipidemia and atherosclerosis

Christopher Brampton
Viola Pomozi
Olivier Le Saux
ResearchOpen Access16 Feb 2021
Scientific Reports

Volume: 11, P: 1-16
Balancing accuracy and cost in machine learning models for detecting medial vascular calcification in chronic kidney disease: a pilot study

Urszula Bialonczyk
Malgorzata Debowska
Jan Poleszczuk
ResearchOpen Access20 May 2025
Scientific Reports

Volume: 15, P: 1-10
Whole-genome sequencing uncovers two loci for coronary artery calcification and identifies ARSE as a regulator of vascular calcification

de Vries, Conomos, Singh and Nicholson et al. identify two additional loci associated with coronary artery calcification (ARSE and MMP16) via a genome-wide association study in 22,400 participants from multiple ancestral groups and prove that ARSE is a mediator of vascular smooth muscle cell calcification and phenotype switching.

Paul S. de Vries
Matthew P. Conomos
Rajeev Malhotra
Research04 Dec 2023
Nature Cardiovascular Research

Volume: 2, P: 1159-1172
Suppression of SIRT1 in Diabetic Conditions Induces Osteogenic Differentiation of Human Vascular Smooth Muscle Cells via RUNX2 Signalling

F. Bartoli-Leonard
F. L. Wilkinson
R. Weston
ResearchOpen Access29 Jan 2019
Scientific Reports

Volume: 9, P: 1-16
Differences in risk factors associated with the initiation and progression of mitral annular calcification in asymptomatic individuals

Kyung An Kim
Hae-Ok Jung
Hyuk-Jae Chang
ResearchOpen Access13 May 2025
Scientific Reports

Volume: 15, P: 1-11
LncRNA NEAT1 sponges miR-214-3p to promote osteoblast differentiation through regulating the PI3K/AKT/mTOR pathway in aortic valve calcification

Rongjian Xu
Yuhui Sun
Min Zhao
ResearchOpen Access21 Apr 2025
Scientific Reports

Volume: 15, P: 1-13
METTL3 obstructs vascular smooth muscle cells osteogenic reprogramming by methylating Runx2 in chronic kidney disease

A mechanistic study on vascular calcification in chronic kidney disease suggests that m6A methyltransferase-3 restrains the crucial osteogenic gene Runx2 expression through mRNA destabilization mediated by the YT 521-B homeodomain family 2.

Meijuan Cheng
Jingjing Jin
Jinsheng Xu
ResearchOpen Access08 Apr 2025
Communications Biology

Volume: 8, P: 1-15
HDAC9 is implicated in atherosclerotic aortic calcification and affects vascular smooth muscle cell phenotype

Genome-wide analyses identify variants near HDAC9 associated with abdominal aortic calcification and other cardiovascular phenotypes. Functional work shows that HDAC9 promotes an osteogenic vascular smooth muscle cell phenotype, enhancing calcification and reducing contractility.

Rajeev Malhotra
Andreas C. Mauer
Christopher J. O’Donnell
Research28 Oct 2019
Nature Genetics

Volume: 51, P: 1580-1587

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