Nature Search

Evaluating the role of the 620W allele of protein tyrosine phosphatase PTPN22 in Crohn's disease and multiple sclerosis

Philip L De Jager
Stephen Sawcer
John D Rioux
Research14 Dec 2005
European Journal of Human Genetics

Volume: 14, P: 317-321
A combination of a particular HLA-DPβ allele and an HLA-DQ heterodimer confers susceptibility to coeliac disease

Teodorica L. Bugawan
Giovanna Angelini
Henry A. Erlich
Research08 Jun 1989
Nature

Volume: 339, P: 470-473
Genome-wide scan reveals association of psoriasis with IL-23 and NF-κB pathways

The Collaborative Association Study of Psoriasis, in partnership with the Genetic Association Information Network (GAIN), reports a genome-wide association study for psoriasis. They identify new replicated associations that highlight a role for the IL-23 and NF-κB pathways in psoriasis susceptibility.

Rajan P Nair
Kristina Callis Duffin
Gonçalo R Abecasis
Research25 Jan 2009
Nature Genetics

Volume: 41, P: 199-204
Erratum: Limited heterogeneity of rearranged T-cell receptor V α transcripts in brains of multiple sclerosis patients

Jorge R. Oksenberg
Simon Stuart
Claude C. A. Bernard
Amendments and Corrections05 Sept 1991
Nature

Volume: 353, P: 94
Association analysis of the 1858C>T polymorphism in the PTPN22 gene in juvenile idiopathic arthritis and other autoimmune diseases

M K Viken
S S Amundsen
B A Lie
Research10 Mar 2005
Genes & Immunity

Volume: 6, P: 271-273
Selection for T-cell receptor Vβ–Dβ–Jβ gene rearrangements with specificity for a myelin basic protein peptide in brain lesions of multiple sclerosis

Jorge R. Oksenberg
Michael A. Panzara
Lawrence Steinman
Research01 Mar 1993
Nature

Volume: 362, P: 68-70
Limited heterogeneity of rearranged T-cell receptor Vα transcripts in brains of multiple sclerosis patients

Jorge R. Oksenberg
Simon Stuart
Claude C. A. Bernard
Research24 May 1990
Nature

Volume: 345, P: 344-346
Recent origin of HLA-DRB1 alleles and implications for human evolution

Tomas F. Bergström
Agnetha Josefsson
Ulf Gyllensten
Research01 Mar 1998
Nature Genetics

Volume: 18, P: 237-242
HLA-DQ_β gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus

John A. Todd
John I. Bell
Hugh O. McDevitt
Research21 Oct 1987
Nature

Volume: 329, P: 599-604
HLA DR–DQ associations with cervical carcinoma show papillomavirus–type specificity

Raymond J. Apple
Henry A. Erlich
Cosette M. Wheeler
Research01 Feb 1994
Nature Genetics

Volume: 6, P: 157-162
HLA class II alleles and susceptibility and resistance to insulin dependent diabetes mellitus in Mexican-American families

Henry A. Erlich
Adina Zeidler
Jerome I. Rotter
Research01 Apr 1993
Nature Genetics

Volume: 3, P: 358-364
Influence of combinations of human major histocompatibility complex genes on the course of HIV–1 infection

R.A. Kaslow
M. Carrington
D.L. Mann
Research01 Apr 1996
Nature Medicine

Volume: 2, P: 405-411
Further investigation of the role of HLA-DPB1 in adult Hodgkin’s disease (HD) suggests an influence on susceptibility to different HD subtypes

G M Taylor
D A Gokhale
J A Radford
ResearchOpen Access11 Jun 1999
British Journal of Cancer

Volume: 80, P: 1405-1411
Prevention of diabetes in non-obese diabetic I-A^k transgenic mice

Robyn M. Slattery
Lars Kjer-Nielsen
Jacques F. A. P. Miller
Research21 Jun 1990
Nature

Volume: 345, P: 724-726
Alignment of radio and optical orientations in high-redshift radio galaxies

K. C. Chambers
G. K. Miley
W. van Breugel
Research21 Oct 1987
Nature

Volume: 329, P: 604-606
A hypothetical model of the foreign antigen binding site of Class II histocompatibility molecules

Jerry H. Brown
Theodore Jardetzky
Don C. Wiley
Research28 Apr 1988
Nature

Volume: 332, P: 845-850
PTPN22 and autoimmune disease

Protein tyrosine phosphatases (PTPs) have diverse roles as negative regulators of stimulatory signaling cascades and are widely recognized as key to maintaining immune cellular homeostasis. Recent data implicating the PTP Lyp in susceptibility to four autoimmune diseases attests to the biological importance of PTP immune regulatory roles and to the etiologic relatedness of different autoimmune conditions.

Katherine A Siminovitch
News & Views01 Dec 2004
Nature Genetics

Volume: 36, P: 1248-1249
Primer: SNP-associated studies and what they can teach us

A major source of genetic heterogeneity is derived from single base-pair alterations in the DNA sequence. The presence of these single-nucleotide polymorphisms can be measured and analyzed, and can potentially be used, therefore, to investigate genetic heterogeneity, to identify disease-associated variants and, in the future, to develop tailored clinical approaches for individual patients with rheumatic diseases.

Ryo Yamada
Reviews04 Mar 2008
Nature Clinical Practice Rheumatology

Volume: 4, P: 210-217
Genetics and epigenetics of rheumatoid arthritis

A rational approach to the management of rheumatoid arthritis (RA) begins with understanding the disease, development of which can be influenced by environmental, genetic and epigenetic factors. Genetic and epigenetic data in RA are revealing insights into pathogenesis and revitalizing the shared epitope hypothesis. These advances are discussed in this Review, alongside approaches to integrating the findings of genetic and functional studies.

Sebastien Viatte
Darren Plant
Soumya Raychaudhuri
Reviews05 Feb 2013
Nature Reviews Rheumatology

Volume: 9, P: 141-153
The PTPN22 R620W polymorphism associates with RF positive rheumatoid arthritis in a dose-dependent manner but not with HLA-SE status

A T Lee
W Li
P K Gregersen
Research23 Dec 2004
Genes & Immunity

Volume: 6, P: 129-133
PTPN22: the archetypal non-HLA autoimmunity gene

SNPs ofPTPN22, a 'shared autoimmunity gene', are important risk factors for rheumatoid arthritis, juvenile idiopathic arthritis and other autoimmune diseases. In this article, Stanford and Bottini review the function of mouse and human PTPN22 in Toll-like receptor and lymphocyte antigen-receptor signalling pathways, and suggest functional models for the involvement of PTPN22 variants in the pathogenesis of autoimmune diseases.

Stephanie M. Stanford
Nunzio Bottini
Reviews08 Jul 2014
Nature Reviews Rheumatology

Volume: 10, P: 602-611
Short tandem repeat (STR) haplotypes in HLA: an integrated 50-kb STR/linkage disequilibrium/gene map between the RING3 and HLA-B genes and identification of STR haplotype diversification in the class III region

Igor Vorechovsky
Jana Kralovicova
Lennart Hammarström
Research30 Aug 2001
European Journal of Human Genetics

Volume: 9, P: 590-598
Haploidentical family member transplants for patients with chronic myeloid leukaemia: a report of the Chronic Leukaemia Working Party of the European Group for Blood and Marrow Transplantation (EBMT)

DE Speiser
J Hermans
JF Apperley
Research01 Jun 1997
Bone Marrow Transplantation

Volume: 19, P: 1197-1203
Common variants at CD40 and other loci confer risk of rheumatoid arthritis

Robert Plenge and colleagues report the results of a meta-analysis of published genome-wide association studies that led to the identification of two previously unknown variants associated with rheumatoid arthritis.

Soumya Raychaudhuri
Elaine F Remmers
Robert M Plenge
Research14 Sept 2008
Nature Genetics

Volume: 40, P: 1216-1223
REL, encoding a member of the NF-κB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis

Peter Gregersen and colleagues report that common variants at the REL locus are associated with risk of rheumatoid arthritis. REL encodes a member of the NF-κB family of transcription factors, which play key roles in coordinating immune and inflammatory responses.

Peter K Gregersen
Chistopher I Amos
Katherine A Siminovitch
Research07 Jun 2009
Nature Genetics

Volume: 41, P: 820-823
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci

Eli Stahl and colleagues report results of a genome-wide association study meta-analysis and replication study for rheumatoid arthritis. Their work identifies several new risk loci and highlights genetic overlap with other autoimmune diseases.

Eli A Stahl
Soumya Raychaudhuri
Robert M Plenge
Research09 May 2010
Nature Genetics

Volume: 42, P: 508-514
Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk

Soumya Raychaudhuri and colleagues demonstrate the utility of GRAIL, a software program used to prioritize results from genome-wide association studies for further replication, applied here to rheumatoid arthritis. The authors seek replication of their predictions in additional independent cohorts and report three new genetic loci associated with RA susceptibility.

Soumya Raychaudhuri
Brian P Thomson
Robert M Plenge
Research08 Nov 2009
Nature Genetics

Volume: 41, P: 1313-1318
Five common gene variants identify elevated genetic risk for coronary heart disease

Lance A Bare
Alanna C Morrison
Eric Boerwinkle
Research01 Oct 2007
Genetics in Medicine

Volume: 9, P: 682-689
Finnish case–control and family studies support PTPN22 R620W polymorphism as a risk factor in rheumatoid arthritis, but suggest only minimal or no effect in juvenile idiopathic arthritis

M F Seldin
R Shigeta
J Tuomilehto
Research18 Aug 2005
Genes & Immunity

Volume: 6, P: 720-722
HLA-associated susceptibility to childhood B-cell precursor ALL: definition and role of HLA-DPB1 supertypes

G M Taylor
A Hussain
M F Greaves
ResearchOpen Access11 Mar 2008
British Journal of Cancer

Volume: 98, P: 1125-1131
Variants in the 5q31 cytokine gene cluster are associated with psoriasis

M Chang
Y Li
S J Schrodi
Research13 Dec 2007
Genes & Immunity

Volume: 9, P: 176-181
Expression levels for many genes in human peripheral blood cells are highly sensitive to ex vivo incubation

E C Baechler
F M Batliwalla
T W Behrens
Research03 Jun 2004
Genes & Immunity

Volume: 5, P: 347-353
Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity

Richard Trembath and colleagues report a meta-analysis of genome-wide association studies for psoriasis, including 2 cohorts genotyped on the custom Immunochip array, in a total of 10,588 cases and 22,806 controls. They identify 15 new susceptibility loci and refine signals in previously known loci, highlighting a role for innate host defense in susceptibility to psoriasis.

Lam C Tsoi
Sarah L Spain
Richard C Trembath
Research11 Nov 2012
Nature Genetics

Volume: 44, P: 1341-1348
Detailed genetic characterization of the interleukin-23 receptor in psoriasis

V E Garcia
M Chang
S J Schrodi
Research24 Jul 2008
Genes & Immunity

Volume: 9, P: 546-555
Factor V Leiden and thrombosis in patients with systemic lupus erythematosus: a meta-analysis

R Kaiser
J L Barton
L A Criswell
Research07 May 2009
Genes & Immunity

Volume: 10, P: 495-502
Genome-wide association analysis implicates the involvement of eight loci with response to tocilizumab for the treatment of rheumatoid arthritis

J Wang
A T Bansal
Adam Platt
ResearchOpen Access10 Apr 2012
The Pharmacogenomics Journal

Volume: 13, P: 235-241

Search

Evaluating the role of the 620W allele of protein tyrosine phosphatase PTPN22 in Crohn's disease and multiple sclerosis

A combination of a particular HLA-DPβ allele and an HLA-DQ heterodimer confers susceptibility to coeliac disease

Genome-wide scan reveals association of psoriasis with IL-23 and NF-κB pathways

Erratum: Limited heterogeneity of rearranged T-cell receptor V α transcripts in brains of multiple sclerosis patients

Association analysis of the 1858C>T polymorphism in the PTPN22 gene in juvenile idiopathic arthritis and other autoimmune diseases

Selection for T-cell receptor Vβ–Dβ–Jβ gene rearrangements with specificity for a myelin basic protein peptide in brain lesions of multiple sclerosis

Limited heterogeneity of rearranged T-cell receptor Vα transcripts in brains of multiple sclerosis patients

Recent origin of HLA-DRB1 alleles and implications for human evolution

HLA-DQ_β gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus

HLA DR–DQ associations with cervical carcinoma show papillomavirus–type specificity

HLA class II alleles and susceptibility and resistance to insulin dependent diabetes mellitus in Mexican-American families

Influence of combinations of human major histocompatibility complex genes on the course of HIV–1 infection

Further investigation of the role of HLA-DPB1 in adult Hodgkin’s disease (HD) suggests an influence on susceptibility to different HD subtypes

Prevention of diabetes in non-obese diabetic I-A^k transgenic mice

Alignment of radio and optical orientations in high-redshift radio galaxies

A hypothetical model of the foreign antigen binding site of Class II histocompatibility molecules

PTPN22 and autoimmune disease

Primer: SNP-associated studies and what they can teach us

Genetics and epigenetics of rheumatoid arthritis

The PTPN22 R620W polymorphism associates with RF positive rheumatoid arthritis in a dose-dependent manner but not with HLA-SE status

PTPN22: the archetypal non-HLA autoimmunity gene

Short tandem repeat (STR) haplotypes in HLA: an integrated 50-kb STR/linkage disequilibrium/gene map between the RING3 and HLA-B genes and identification of STR haplotype diversification in the class III region

Haploidentical family member transplants for patients with chronic myeloid leukaemia: a report of the Chronic Leukaemia Working Party of the European Group for Blood and Marrow Transplantation (EBMT)

Common variants at CD40 and other loci confer risk of rheumatoid arthritis

REL, encoding a member of the NF-κB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis

Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci

Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk

Five common gene variants identify elevated genetic risk for coronary heart disease

Finnish case–control and family studies support PTPN22 R620W polymorphism as a risk factor in rheumatoid arthritis, but suggest only minimal or no effect in juvenile idiopathic arthritis

HLA-associated susceptibility to childhood B-cell precursor ALL: definition and role of HLA-DPB1 supertypes

Variants in the 5q31 cytokine gene cluster are associated with psoriasis

Expression levels for many genes in human peripheral blood cells are highly sensitive to ex vivo incubation

Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity

Detailed genetic characterization of the interleukin-23 receptor in psoriasis

Factor V Leiden and thrombosis in patients with systemic lupus erythematosus: a meta-analysis

Genome-wide association analysis implicates the involvement of eight loci with response to tocilizumab for the treatment of rheumatoid arthritis

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