Nature Search

Stem cells: The cell division

Oliver Brüstle fought for more than a decade to pursue and patent human embryonic stem-cell research in Germany. Now his efforts have backfired.

Alison Abbott
News14 Dec 2011
Nature

Volume: 480, P: 310-312
European court clears way for stem-cell patents

A ruling from the European Court of Justice lifts 2011 ban on patenting embryonic stem cells made from unfertilized eggs.

Ewen Callaway
Alison Abbott
News18 Dec 2014
Nature
In vitro differentiation of transplantable neural precursors from human embryonic stem cells

Su-Chun Zhang
Marius Wernig
James A. Thomson
Research01 Dec 2001
Nature Biotechnology

Volume: 19, P: 1129-1133
Human embryonic stem cells — the German debate

Eve-Marie Engels
Comments & Opinion01 Aug 2002
Nature Reviews Genetics

Volume: 3, P: 636-641
Germany hits science high

But election prompts fears that budgetary pressures may sap strong investment.

Quirin Schiermeier
News18 Sept 2013
Nature

Volume: 501, P: 289-290
Neutrophil extracellular traps and their histones promote Th17 cell differentiation directly via TLR2

Neutrophils are critical in the immune response to infective agents and have multiple effector strategies including the production of extracellular traps termed NETs. Here the authors show a link between NET production and Th17 differentiation which mechanistically occurs downstream of TLR2 signalling.

Alicia S. Wilson
Katrina L. Randall
Anne Brüstle
ResearchOpen Access26 Jan 2022
Nature Communications

Volume: 13, P: 1-12
Stem cell therapy market

Products based on stem cells show promise in diverse therapeutic areas, including cardiovascular and autoimmune diseases. This article analyses the late-stage pipeline of stem cell therapies and provides a market overview.

Basharut A. Syed
James B. Evans
Comments & Opinion01 Mar 2013
Nature Reviews Drug Discovery

Volume: 12, P: 185-186
Whole-brain 3D mapping of human neural transplant innervation

Transplantation of cells into the central nervous system has developed into a major avenue for replacing neurons lost to neurodegenerative disease. Here the authors develop an approach combining viral-based transynaptic tracing labeling and whole brain imaging to trace synaptic innervation of human neurons transplanted into a mouse background.

Jonas Doerr
Martin Karl Schwarz
Oliver Brüstle
ResearchOpen Access19 Jan 2017
Nature Communications

Volume: 8, P: 1-7
Anthrax toxins regulate pain signaling and can deliver molecular cargoes into ANTXR2⁺ DRG sensory neurons

Discovering that nociceptive sensory neurons express the receptor for anthrax toxin, Yang et al. show that anthrax toxin can induce potent analgesia in mice and facilitate the delivery of potentially analgesic cargo proteins into nociceptive neurons.

Nicole J. Yang
Jörg Isensee
Isaac M. Chiu
Research20 Dec 2021
Nature Neuroscience

Volume: 25, P: 168-179
Antigen receptor-mediated depletion of FOXP3 in induced regulatory T-lymphocytes via PTPN2 and FOXO1

Antigen stimulation in vivocan reprogram T regulatory cells to lose the expression of Foxp3 and become effector cells. Here the authors show that the mechanism involves dephosphorylation of STAT5 by PTPN2 and downregulation of Foxo1 by miR-182.

Evita Bothur
Hartmann Raifer
Michael Lohoff
ResearchOpen Access13 Oct 2015
Nature Communications

Volume: 6, P: 1-12
IL-17-producing γδ T cells switch migratory patterns between resting and activated states

IL-17-producing γδ T (γδT17) cells position in barrier tissues but also home to inflammatory sites. How this trafficking is regulated is unclear. Here the authors show that the dynamic expression of chemokine receptors CCR2 and CCR6 differentiates γδT17 cell trafficking patterns at homeostasis and in inflammatory scenarios.

Duncan R. McKenzie
Ervin E. Kara
Shaun R. McColl
ResearchOpen Access05 Jun 2017
Nature Communications

Volume: 8, P: 1-13
A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation

Induced neurons, but not induced pluripotent stem cell (iPSC)-derived neurons, preserve age-related traits. Here, the authors demonstrate that blood-derived induced neural stem cells (iNSCs), despite lacking a pluripotency transit, lose age-related signatures.

Chao Sheng
Johannes Jungverdorben
Oliver Brüstle
ResearchOpen Access02 Oct 2018
Nature Communications

Volume: 9, P: 1-15
T cell co-stimulation and co-inhibition in cardiovascular disease: a double-edged sword

This Review summarizes the preclinical data on the role of T cell co-stimulatory and co-inhibitory pathways in cardiovascular disease (CVD) and discusses the therapeutic potential of targeting co-stimulation and inhibition molecules to treat CVD, as well as the evidence of an association between the use of immune checkpoint inhibitors and cardiovascular toxicity.

Karin H. Simons
Alwin de Jong
Paul H. A. Quax
Reviews15 Feb 2019
Nature Reviews Cardiology

Volume: 16, P: 325-343
Embryonic stem cell-based reduction of central nervous system sulfatide storage in an animal model of metachromatic leukodystrophy

D Klein
T Schmandt
O Brüstle
Research27 Jul 2006
Gene Therapy

Volume: 13, P: 1686-1695
High-resolution DNA analysis of human embryonic stem cell lines reveals culture-induced copy number changes and loss of heterozygosity

Cultured human embryonic stem cells often acquire chromosomal abnormalities that could be detrimental in certain applications. Närvä et al. report the highest-resolution genetic analysis of these cells to date and identify genes whose expression is altered by culture-induced genetic changes.

Elisa Närvä
Reija Autio
Riitta Lahesmaa
Research28 Mar 2010
Nature Biotechnology

Volume: 28, P: 371-377
Leveling Waddington: the emergence of direct programming and the loss of cell fate hierarchies

During cell reprogramming and direct cell fate conversion, changes in somatic and pluripotent cell fates do not require the passage through a hierarchy of distinct cell fates that are proposed to occur during normal development and are consistent with the original Waddington model. Instead, a 'flat epigenetic disc' model might explain cell fate transitions during these processes.

Julia Ladewig
Philipp Koch
Oliver Brüstle
Reviews13 Mar 2013
Nature Reviews Molecular Cell Biology

Volume: 14, P: 225-236
G-Force PD: a global initiative in coordinating stem cell-based dopamine treatments for Parkinson’s disease

Roger A Barker
Lorenz Studer
Jun Takahashi
ReviewsOpen Access24 Sept 2015
npj Parkinson's Disease

Volume: 1, P: 1-5
Identification of adeno-associated virus variants for gene transfer into human neural cell types by parallel capsid screening

Lea Jessica Flitsch
Kathleen Börner
Oliver Brüstle
ResearchOpen Access19 May 2022
Scientific Reports

Volume: 12, P: 1-12
GSTO1-1 plays a pro-inflammatory role in models of inflammation, colitis and obesity

Deepthi Menon
Ashlee Innes
Philip G. Board
ResearchOpen Access19 Dec 2017
Scientific Reports

Volume: 7, P: 1-15
Erratum: Modeling psychiatric disorders: from genomic findings to cellular phenotypes

A Falk
V M Heine
S Djurovic
Amendments and Corrections21 Jun 2016
Molecular Psychiatry

Volume: 21, P: 1321
MALT1 is an intrinsic regulator of regulatory T cells

A Brüstle
D Brenner
T W Mak
ResearchOpen Access25 Sept 2015
Cell Death & Differentiation

Volume: 24, P: 1214-1223
Evaluating cell reprogramming, differentiation and conversion technologies in neuroscience

Cultures of human neural cells can be generated from skin cells that have been reprogrammed to produce induced pluripotent stem cells (iPSCs) or subjected to direct conversion. Gage and colleagues describe advances in differentiation protocols that allow specific subtypes of neural cell to be produced and consider the advantages and disadvantages of different approaches.

Jerome Mertens
Maria C. Marchetto
Fred H. Gage
Reviews19 May 2016
Nature Reviews Neuroscience

Volume: 17, P: 424-437
Cadherin-13 is a critical regulator of GABAergic modulation in human stem-cell-derived neuronal networks

Britt Mossink
Jon-Ruben van Rhijn
Nael Nadif Kasri
ResearchOpen Access10 May 2021
Molecular Psychiatry

Volume: 27, P: 1-18
The interaction between caveolin-1 and Rho-GTPases promotes metastasis by controlling the expression of alpha5-integrin and the activation of Src, Ras and Erk

E Arpaia
H Blaser
T W Mak
ResearchOpen Access18 Jul 2011
Oncogene

Volume: 31, P: 884-896
Toso regulates differentiation and activation of inflammatory dendritic cells during persistence-prone virus infection

P A Lang
A Meryk
K S Lang
Research26 Sept 2014
Cell Death & Differentiation

Volume: 22, P: 164-173
Modeling psychiatric disorders: from genomic findings to cellular phenotypes

A Falk
V M Heine
S Djurovic
ReviewsOpen Access31 May 2016
Molecular Psychiatry

Volume: 21, P: 1167-1179
Notch1 signaling promotes survival of glioblastoma cells via EGFR-mediated induction of anti-apoptotic Mcl-1

A Fassl
K E Tagscherer
W Roth
Research16 Jan 2012
Oncogene

Volume: 31, P: 4698-4708
PTPN12 promotes resistance to oxidative stress and supports tumorigenesis by regulating FOXO signaling

I S Harris
H Blaser
T W Mak
Research25 Feb 2013
Oncogene

Volume: 33, P: 1047-1054

Search

Stem cells: The cell division

European court clears way for stem-cell patents

In vitro differentiation of transplantable neural precursors from human embryonic stem cells

Human embryonic stem cells — the German debate

Germany hits science high

Neutrophil extracellular traps and their histones promote Th17 cell differentiation directly via TLR2

Stem cell therapy market

Whole-brain 3D mapping of human neural transplant innervation

Anthrax toxins regulate pain signaling and can deliver molecular cargoes into ANTXR2⁺ DRG sensory neurons

Antigen receptor-mediated depletion of FOXP3 in induced regulatory T-lymphocytes via PTPN2 and FOXO1

IL-17-producing γδ T cells switch migratory patterns between resting and activated states

A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation

T cell co-stimulation and co-inhibition in cardiovascular disease: a double-edged sword

Embryonic stem cell-based reduction of central nervous system sulfatide storage in an animal model of metachromatic leukodystrophy

High-resolution DNA analysis of human embryonic stem cell lines reveals culture-induced copy number changes and loss of heterozygosity

Leveling Waddington: the emergence of direct programming and the loss of cell fate hierarchies

G-Force PD: a global initiative in coordinating stem cell-based dopamine treatments for Parkinson’s disease

Identification of adeno-associated virus variants for gene transfer into human neural cell types by parallel capsid screening

GSTO1-1 plays a pro-inflammatory role in models of inflammation, colitis and obesity

Erratum: Modeling psychiatric disorders: from genomic findings to cellular phenotypes

MALT1 is an intrinsic regulator of regulatory T cells

Evaluating cell reprogramming, differentiation and conversion technologies in neuroscience

Cadherin-13 is a critical regulator of GABAergic modulation in human stem-cell-derived neuronal networks

The interaction between caveolin-1 and Rho-GTPases promotes metastasis by controlling the expression of alpha5-integrin and the activation of Src, Ras and Erk

Toso regulates differentiation and activation of inflammatory dendritic cells during persistence-prone virus infection

Modeling psychiatric disorders: from genomic findings to cellular phenotypes

Notch1 signaling promotes survival of glioblastoma cells via EGFR-mediated induction of anti-apoptotic Mcl-1

PTPN12 promotes resistance to oxidative stress and supports tumorigenesis by regulating FOXO signaling

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