Jacob George and colleagues examine whether the association of the IFNL3–IFNL4 region with hepatic inflammation and fibrosis is mediated by IFN-λ3 or IFN-λ4. They find greater hepatic inflammation, fibrosis progression rate and hepatic infiltration of immune cells in individuals with the risk haplotype that produces IFN-λ3 but not IFN-λ4.
- Mohammed Eslam
- Duncan McLeod
- Rosanna Santoro
