Nature Search

The 201 Trial: a placebo-controlled randomized phase 2 study of safety and tolerance of the c-Abl kinase inhibitor risvodetinib in untreated Parkinson’s disease

Werner et al. present the results of the 201 Trial, a 12-week randomized, double-blind placebo-controlled phase 2a study of risvodetinib, in patients with early untreated Parkinson’s disease. Risvodetinib was found to be safe and well tolerated.

M. H. Werner
A. McGarry
C. W. Olanow
ResearchOpen Access20 Feb 2026
Nature Aging

P: 1-10
Differential repair of O⁶-methylguanine in DNA of rat hepatocytes and nonparenchymal cells

J. G. Lewis
J. A. Swenberg
Research13 Nov 1980
Nature

Volume: 288, P: 185-187
Immune checkpoint inhibition increases antigen-specific T cell response in head and neck cancer

Patrick J. Schuler
Franziska Oliveri
Jochen Greiner
ResearchOpen Access09 Feb 2026
Scientific Reports

Volume: 16, P: 1-11
Cell viscosity influences haematogenous dissemination and metastatic extravasation of tumour cells

The viscosity of tumour cells is shown to govern their ability to disseminate through the bloodstream and extravasate, establishing a key biomechanical factor of metastasis.

Valentin Gensbittel
Zeynep Yesilata
Jacky G. Goetz
Research19 Jan 2026
Nature Materials

P: 1-12
Changes in Titanium Dioxide–Silver Nitrate Mixtures after Ultra-violet Irradiation

W. C. CLARK
A. VONDJIDIS
Research08 Aug 1964
Nature

Volume: 203, P: 635-636
Influence of Hunger on Olfactory Acuity

H. W. BERG
R. M. PANGBORN
A. D. WEBB
Research05 Jan 1963
Nature

Volume: 197, P: 108
Comparing decentralized machine learning and AI clinical models to local and centralized alternatives: a systematic review

José Miguel Diniz
Henrique Vasconcelos
Alberto Freitas
ResearchOpen Access14 Feb 2026
npj Digital Medicine

Volume: 9, P: 1-26
The Liquid State at the Absolute Zero and the Third Law of Thermodynamics

A. R. MILLER
Research20 Aug 1949
Nature

Volume: 164, P: 325-327
Increased deciduous tree dominance reduces wildfire carbon losses in boreal forests

More frequent fires in the North American boreal are causing shifts from conifer to deciduous forests. This study finds that when deciduous forests burn, their carbon losses are driven by weather, but are lower than in conifer forests, potentially dampening climate–fire feedbacks.

Betsy Black
Xanthe J. Walker
Michelle C. Mack
Research15 Jan 2026
Nature Climate Change

Volume: 16, P: 187-192
Mouse liver assembloids model periportal architecture and biliary fibrosis

An organoid system comprising adult mouse hepatocytes, cholangiocytes and mesenchymal cells recapitulates liver morphology, biliary function and fibrotic pathology, providing a new model for studies of hepatic biology.

Anna M. Dowbaj
Aleksandra Sljukic
Meritxell Huch
ResearchOpen Access29 May 2025
Nature

Volume: 644, P: 473-482
Measurement of Atmospheric Ozone by a Quick Electrochemical Method

F. A. PANETH
E. GLÜCKAUF
Research17 May 1941
Nature

Volume: 147, P: 614-615
Boosting superconductivity in ultrathin YBa₂Cu₃O_7−δ films via nanofaceted substrates

The authors report an enhancement of the superconducting onset temperature in nanometer-thin YBa₂Cu₃O₇-δ films grown on substrates with nanofaceted surfaces. They theoretically show that the enhancement is mainly driven by electronic nematicity and unidirectional charge density waves, and further suggest that the nanofacets themselves may promote these effects.

Eric Wahlberg
Riccardo Arpaia
Floriana Lombardi
ResearchOpen Access07 Jan 2026
Nature Communications

Volume: 17, P: 1-8
Basement membrane perforations guide anterior–posterior axis formation

Chen et al. show that in mice, extracellular matrix remodeling drives early migration of the anterior signaling center, establishing the body axis sooner than expected—a mechanism potentially conserved in humans.

Dong-Yuan Chen
Nikolas H. Claussen
Magdalena Zernicka-Goetz
ResearchOpen Access22 Jul 2025
Nature Communications

Volume: 16, P: 1-19
Grain Growth in Cadmium

E. N. DA C. ANDRADE
D. A. ABOAV
Research08 Aug 1964
Nature

Volume: 203, P: 635
Freezing-in orientational disorder induces crossover from thermally-activated to temperature-independent transport in organic semiconductors

The electronic properties of organic charge-transfer complexes are highly coupled to their crystallographic structures. Goetz et al.show that the librational motion can mediate a glass-like transition, resulting in a transition from temperature-activated to temperature-independent charge transport.

K. P. Goetz
A. Fonari
O. D. Jurchescu
Research03 Dec 2014
Nature Communications

Volume: 5, P: 1-8
Haemodynamics in the Sauropoda

LYLE A. HOHNKE
Research03 Aug 1973
Nature

Volume: 244, P: 309-310
Synaptic localization of kainic acid binding sites

A. C. Foster
E. E. Mena
C. W. Cotman
Research01 Jan 1981
Nature

Volume: 289, P: 73-75
Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes

A. W. Ford-Hutchinson
M. A. Bray
M. J. H. Smith
Research17 Jul 1980
Nature

Volume: 286, P: 264-265
Proton Magnetic Resonance in a Series of Dimethyl Siloxane Polymers. A Specific Long-Chain Effect?

J. G. POWLES
A. HARTLAND
Research02 Apr 1960
Nature

Volume: 186, P: 26-28
Sensitive Microbiological Detector for Air Pollution

H. A. DRUETT
L. P. PACKMAN
Research18 May 1968
Nature

Volume: 218, P: 699
Erratum: An integrated view of the chemistry and mineralogy of martian soils

Albert S. Yen
Ralf Gellert
Jutta Zipfel
Amendments and Corrections11 Aug 2005
Nature

Volume: 436, P: 881
Tetrapeptides of the eosinophil chemotactic factor of anaphylaxis (ECF-A) enhance eosinophil Fc receptor

M. Capron
A. Capron
K. F. Austen
Research01 Jan 1981
Nature

Volume: 289, P: 71-73
Characteristics of the Zoological Specificity of Some Protein Hormones from the Anterior Pituitary

YVES A. FONTAINE
Research27 Jun 1964
Nature

Volume: 202, P: 1296-1298
Changes of Levels of Infectivity in Incubated Sub-Cellular Elements from Western-Equine-Encephalitis-Infected and Normal Chicken Embryo Cells

G. W. COCHRAN
J. STORZ
A. MIKULSKA-MACHETA
Research27 Jun 1964
Nature

Volume: 202, P: 1294-1296
An open label, non-randomized study assessing a prebiotic fiber intervention in a small cohort of Parkinson’s disease participants

This study found that a prebiotic intervention was well-tolerated and safe, beneficially changed the microbiome, decreased inflammation and a marker of neurodegeneration, with possible clinical effects in Parkinson’s disease (PD) patients. This study offers the rationale for further investigations using prebiotic fibers in PD.

Deborah A. Hall
Robin M. Voigt
Ali Keshavarzian
ResearchOpen Access18 Feb 2023
Nature Communications

Volume: 14, P: 1-14
Spindle-localized F-actin regulates polar MTOC organization and the fidelity of meiotic spindle formation

Errors in oocyte division can cause infertility and birth defects. Here, authors combine a genetic strategy with a novel optochemical tool to show that spindle pole-localized F-actin is essential for proper meiotic spindle assembly and chromosome segregation.

Edgar J. Soto-Moreno
Nourhan N. Ali
Ahmed Z. Balboula
ResearchOpen Access19 Sept 2025
Nature Communications

Volume: 16, P: 1-20
A novel alveolar Krebs cycle-triggered CO2 sensing mechanism regulates regional pulmonary ventilation.

Leoni Schulte-Uentrop
Alwin Goetz
Martina Kiefmann
ResearchOpen Access03 Aug 2011
Nature Precedings

P: 1
Pathobiont-induced suppressive immune imprints thwart T cell vaccine responses

Mechanisms of inefficient vaccine protection against pathobionts such as S. aureus (SA) are still unclear. Here the authors show that prior SA exposure induces non-protective CD4⁺ T cells, which impair IsdB vaccine protection by IL-10 secretion and IL-17A suppression, whereas IL-17A promoting adjuvant CAF01 overcomes this dilemma.

Irshad Ahmed Hajam
Chih-Ming Tsai
George Y. Liu
ResearchOpen Access16 Dec 2024
Nature Communications

Volume: 15, P: 1-16
Demagnetization cooling of a gas

M. Fattori
T. Koch
T. Pfau
Research29 Oct 2006
Nature Physics

Volume: 2, P: 765-768
Cholecystokinin both stimulates and inhibits human food intake

RICHARD A. L. STURDEVANT
HEIDI GOETZ
Research01 Jun 1976
Nature

Volume: 261, P: 713-715
Tissue-intrinsic beta-catenin signals antagonize Nodal-driven anterior visceral endoderm differentiation

The anterior visceral endoderm is an important cell population that positions the head-to-tail axis of the mammalian embryo. Here, Schumacher et al. identify beta-catenin signaling as a key regulator of anterior visceral endoderm differentiation.

Sina Schumacher
Max Fernkorn
Christian Schröter
ResearchOpen Access13 Jun 2024
Nature Communications

Volume: 15, P: 1-15
The impact of CYP2D6-predicted phenotype on tamoxifen treatment outcome in patients with metastatic breast cancer

L A Lammers
R H J Mathijssen
R H N van Schaik
ResearchOpen Access10 Aug 2010
British Journal of Cancer

Volume: 103, P: 765-771
Mode of action of an anti-inflammatory fraction from normal human plasma

J. R. WALKER
M. J. H. SMITH
F. J. BILLIMORIA
Research03 Apr 1975
Nature

Volume: 254, P: 444-446
Dynamic antagonism between key repressive pathways maintains the placental epigenome

Weigert et al. show that an antagonistic relationship between DNA methyltransferase and Polycomb activity is globally responsible for the maintenance of intermediate methylation levels observed in trophoblast stem cells.

Raha Weigert
Sara Hetzel
Alexander Meissner
ResearchOpen Access06 Apr 2023
Nature Cell Biology

Volume: 25, P: 579-591
FOXO1-mediated lipid metabolism maintains mammalian embryos in dormancy

van der Weijden et al. perform genomic, proteomic and metabolic analyses and find that FOXO1-mediated fatty acid oxidation maintains mouse embryos in diapause.

Vera A. van der Weijden
Maximilian Stötzel
Aydan Bulut-Karslioglu
ResearchOpen Access04 Jan 2024
Nature Cell Biology

Volume: 26, P: 181-193
Corrigendum: Major shear zones and autochthonous Dalradian in the north-east Scottish Caledonides

W. A. Ashcroft
B. C. Kneller
M. Munro
Research13 Feb 1986
Nature

Volume: 319, P: 606
Methanol poisoning in the folate-deficient rat

A. B. MAKAR
T. R. TEPHLY
Research01 Jun 1976
Nature

Volume: 261, P: 715-716
Hæmadsorption by Measles Syncytia

A. KOHN
Research17 Mar 1962
Nature

Volume: 193, P: 1088-1089
Phospholipids in Human Lithogenic Gall Bladder Bile

F. ANDERSON
IAN A. D. BOUCHIER
Research25 Jan 1969
Nature

Volume: 221, P: 372-373
Bombesin—satiety or malaise?

J. A. Deutsch
Research19 Jun 1980
Nature

Volume: 285, P: 592
Serum Factor Gm^a among the Iranians

LUBA PODLIACHOUK
A. EYQUEM
M. EFTEKHARI
Research12 Aug 1961
Nature

Volume: 191, P: 717-718
Mechanisms of Disease: the role of heat-shock protein 90 in genitourinary malignancy

Heat shock protein 90 (HSP90) plays a major role in many cancers, including tumors of the prostate and kidney. Its function in cell regulation makes it a potential target for treatments against cancer. This Review provides insights into the role of HSP90 in urologic cancers and discusses the data from clinical trials examining the use of HSP90 inhibitors in the treatment of patients with urologic cancers.

Jean-Baptiste Lattouf
Ramaprasad Srinivasan
Leonard Neckers
Reviews01 Nov 2006
Nature Clinical Practice Urology

Volume: 3, P: 590-601
Behavioural variants of rat neuroblastoma cells

Lloyd A. Culp
Research03 Jul 1980
Nature

Volume: 286, P: 77-79
Myelination of the canine central nervous system by glial cell transplantation: A model for repair of human myelin disease

D.R. Archer
P.A. Cuddon
I.D. Duncan
Research01 Jan 1997
Nature Medicine

Volume: 3, P: 54-59
Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over

Sean M. Baker
Annemieke W. Plug
R. Michael Liskay
Research01 Jul 1996
Nature Genetics

Volume: 13, P: 336-342
Haptoglobin Patterns in Cord Blood Serums

A. R. RAUSEN
P. S. GERALD
L. K. DIAMOND
Research12 Aug 1961
Nature

Volume: 191, P: 717
The germline genetic component of drug sensitivity in cancer cell lines

Little is known about the contribution of germline genetic variants to cancer drug sensitivity. Here, the authors devise an approach for joint analysis of germline variants and somatic mutations, identifying substantial germline contributions to variation in drug sensitivity.

Michael P. Menden
Francesco Paolo Casale
Oliver Stegle
ResearchOpen Access23 Aug 2018
Nature Communications

Volume: 9, P: 1-8
Association of women-specific health factors in the severity of Parkinson’s disease

Shilpa C. Rao
Yadi Li
Ignacio F. Mata
ResearchOpen Access05 Jun 2023
npj Parkinson's Disease

Volume: 9, P: 1-16
Genetic analysis of autoimmune type 1 diabetes mellitus in mice

John A. Todd
Timothy J. Aitman
Linda S. Wicker
Research13 Jun 1991
Nature

Volume: 351, P: 542-547
In vivo modulation of endothelial polarization by Apelin receptor signalling

Endothelial cells align in the direction of flow in response to shear stress. Here the authors describe a zebrafish model for visualization of endothelial polarization and demonstrate that endothelial cell alignment depends on blood flow and Apelin signalling.

Hyouk-Bum Kwon
Shengpeng Wang
Didier Y. R. Stainier
ResearchOpen Access01 Jun 2016
Nature Communications

Volume: 7, P: 1-12

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