Search

The correlations exhibited by multipartite quantum systems composed of more than two entangled subsystems are more difficult to describe than those of bipartite quantum systems. Fritzet al.propose a principle of 'local orthogonality' as a key element to describing multipartite quantum correlations.

Practical implementations of quantum communication need to securely deliver information over long distances without line-of-sight. Towards this goal, Cuevas et al.use an actively stabilized interferometer to close the geometry loophole for a Bell inequality violation over 1 km of optical fibre.

Contextuality theorem could improve secure communication.

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Nitrogen fixation in oceans is facilitated by associations between marine phytoplankton and cyanobacteria such as UCYN-A. Here, Cornejo-Castillo et al. show that UCYN-A diversified in the late Cretaceous under strong purifying selection to become lineage-specific symbiont partners with different prymnesiophytes.

Nitrogen-fixing (diazotrophic) cyanobacteria provide a critical nutrient input to the ocean. Non-cyanobacterial diazotrophs are also thought to contribute, but they have not been observed to fix nitrogen. Using dual isotope labeling combined with nanoscale secondary ion mass spectrometry, this study demonstrates that putative non-cyanobacterial diazotrophs attached to particles can fix nitrogen.

This cross-sectional study in two independent middle-aged and aged cohorts investigates whether psychological characteristics associated with varying dementia risk aggregate into psychological profiles and relate to aging brain health.

The authors generated a species-guided phylogeny of eukaryotic iGluRs, alongside a focused analysis of iGluR homologues from the early-branching invertebrate phylum Placozoa.

The metal-organic framework TAMOF-1 offers high performance for CO₂ capture and purification from model biogas streams, thanks to its high CO₂ adsorption potential, good stability in humid conditions, and energy-efficient regeneration.

The vast scale of emerging on-demand chemical collections presents a challenge for efficiently identifying promising drug candidates. Here, the authors develop a bottom-up computational strategy to first explore fragment space and then exploit the most promising scaffolds, successfully identifying diverse and potent BRD4 binders.

Machine learning can be used to identify subtypes of psychiatric disease. Here the authors identified two neurostructural subgroups in schizophrenia, each showing reproducibility and generalizability across different collection locations and illness stages, using the SuStain algorithm.

Two products of the anal microbiome improve the specificity and sensitivity of diagnosing high-grade precursor lesions to anal cancer over cytology.

Tuberculosis is a major cause of mortality, and the rise of drug-resistant strains of Mycobacterium tuberculosis requires the urgent development of safe and effective treatments. In this work, the authors develop a compound against lysyl-tRNA synthetase, demonstrating on-target mechanism of action and efficacy in vivo.

An investigation using various methods reports an association between adeno-associated virus 2 and paediatric hepatitis of unknown aetiology.

We report observations of ceers-2112 that show that this galaxy, at a redshift of 3, unexpectedly has a barred spiral structure.

Self-organising systems have huge potential in device design and fabrication; however, demonstrations of this are limited. Here, the authors report on a combination of disordered proteins and graphene oxide which allows spatio-temporal patterning and demonstrate the fabrication of microfluidic devices.

A case–control study investigating the causes of recent cases of acute hepatitis of unknown aetiology in 32 children identifies an association between adeno-associated virus infection and host genetics in disease susceptibility.

Amphiphilic-peptide-driven opening of elastin-like protein molecules triggers the self-assembly of a multilayered membrane. This dynamic system can undergo morphogenesis into hierarchically ordered tubular structures that can be used to create complex scaffolds for tissue engineering.

The question of whether quantum phenomena can be explained by classical models with hidden variables is the subject of a long-lasting debate. One feature of classical models that is thought to be in conflict with quantum mechanics is non-contextuality, with experiments undertaken with photons and neutrons seeming to support this. However, these tests required the generation of special quantum states and left various loopholes open. Here an experiment is performed with trapped ions that overcomes these problems and cannot be explained in non-contextual terms.

A step towards an improved method of fullerene production was the recently reported synthesis of a precursor and its subsequent dehydrogenation to C₆₀. Otero et al. show that when depositing precursors on a platinum surface and heating to 750 K, most precursors are transformed into the corresponding fullerenes.

We find a diverse and active particle-associated non-cyanobacterial diazotroph community in the mesopelagic zone of the North Pacific Gyre, suggesting a significant contribution to pelagic nitrogen fixation and challenging the cyanobacteria-driven paradigm.

Hidalgo and colleagues describe a cell-intrinsic program that induces changes in the proteome, granule content and NET-forming capacity of neutrophils and is driven by the chemokine receptor CXCR2 and regulators of the circadian clock.

The description of a compound (DDD107498) with antimalarial activity against multiple life-cycle stages of Plasmodium falciparum and good pharmacokinetic and safety properties, with potential for single-dose treatment, chemoprotection and prevention of transmission.

There is evidence that disordered proteins play a role in the mineralization process. Here, the authors report on the development of elastin-like recombinant protein membranes using disordered-ordered interplay to investigate and guide mineralization.

The RNA component telomerase (TERC) has a critical non-canonical role in the formation of the myeloid lineage. Here, the authors show aptamers that mimic the behaviour of the entire TERC molecule in myelopoiesis activation.

The epigenetic factor Bmi1 regulates self-renewal of many adult stem cells, but its role in heart function is unknown. Here the authors show that Bmi1 prevents cardiac senescence by inhibiting the tumor suppressor protein p16^INK4ain adult mice, protecting them from dilated cardiomyopathy and heart failure.

The relative contribution of nitrogen fixation and nitrogen diffusion to marine biomes is presently debated. Here, the authors evaluate the contribution of these pathways across the tropics and subtropics of the global ocean and show that nitrogen diffusion, reinforced by salt fingers, is the dominant process.