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Weakly coordinating anions are commonly used to stabilize high-valent, electrophilic transition-metal complexes, owing to their low nucleophilicity and minimal coordinating ability. Here, the authors report a cobalt platform that generates a directional, protic cavity for ion pairing.

Cholera remains a significant public health burden in sub-Saharan Africa, but the mechanisms of continental and regional spread remain undefined. Here, the authors investigate recent patterns of spread using Vibrio cholerae genomic surveillance data collected by a consortium of seven African Union member states from 2019-2024.

People living with HIV (PLWH) have an increased risk for aging-related comorbidities. Here, the authors develop a proteomics-based immune aging framework for PLWH and demonstrate that immune aging is accelerated in HIV infection, is closely linked to total viral reservoir burden, and is modulated by antiretroviral therapy.

Diamond anvils are widely used in high-pressure research to investigate matter under extreme conditions. Here, broadband spectroscopy is used to measure pressure-driven opacity of diamond anvils to 520 GPa, revealing bandgap narrowing and optical behavior that redefines the limits of high-pressure spectroscopy.

Long-term patterns of physical activity and the importance of consistent adherence to the recommended level remain poorly understood. Here, the authors show that maintaining physical activity over the long term offers added benefits beyond activity volume alone for chronic disease prevention.

Wnt signaling is activated in more than half of gastric cancers through a ligand-dependent manner. Here the authors show with mouse models that tumor-derived Wnt ligands activate liver stromal fibroblasts to facilitate hyaluronan accumulation in the microenvironment, promoting gastric cancer liver metastasis.

In this study, the authors develop a stoichiometric-thermodynamic model linking seismic decarbonation to Mw 5.9–6.5 earthquakes. They demonstrate that seismic CO₂ pressurization can sustain dynamic slip and enhance the destructive potential of earthquakes.

This paper presents an active pixel power control (APPC) to minimize crosstalk in all-optical neural interrogation. Tested in vivo, APPC suppresses optogenetic artifacts while preserving Ca2+ imaging quality, enabling precise neural circuit analysis.

Direct air capture (DAC) removes CO₂ from the atmosphere but remains energy-intensive at scale. Here, the authors integrate catalytic solvent regeneration and hybrid solvents with low-temperature membrane vacuum regeneration, significantly improving the energy efficiency and sustainability of liquid-based DAC systems.

Most studies assessing food self-sufficiency look at calories and neglect nutrient gaps. Comparing food demand and potential food production under land and water constraints, this study quantifies 9 key nutrient gaps for each of African’s 54 countries.

CRISPR/Cas9 screens have identified genetic contributions to many phenotypes. However, studying combinations of genes or regulatory elements remains challenging. Here, the authors use CRISPR/Cas12a to overcome those challenges and enable new approaches to study combinatorial genetic mechanisms.

The authors demonstrate that targeted protein degradation of the dengue virus capsid suppresses infection through capsid-dependent pathways rather than classical inhibition, revealing a new antiviral strategy effective against resistant viral variants.

MASH is driven by the secreted GPNMB ectodomain, which binds hepatocyte RYK to activate ERK1/2 and promote lipid uptake and lipogenic programs; blocking the GPNMB–RYK axis prevented and treated MASH in preclinical models.

Given rising diabetes prevalence globally, access to diabetes treatments is gaining urgency. Here, the authors show patterns of glucose-lowering medication use for diabetes across 62 low- and middle-income countries.

Neoantigen-based adoptive T cell therapies represent a personalized approach for cancer immunotherapy. Here the authors describe NEO-STIM, an ex vivo T cell induction platform to STIMulate peripheral blood T cells to generate responses against tumor NEOantigens.

Ribosomes drive protein synthesis, but their dynamics are hard to visualize. Here, authors introduce RiboBright, a fluorescent probe that illuminates ribosomes in live and fixed cells, revealing cell-type-specific content, organization, and movement.

The open interfaces of a three-dimensional all-dielectric photonic topological insulator operate as effective metasurfaces with helical surface states, enabling spin-dependent steering and directional control of far-field surface state emission.

Kv7.4 channels regulate auditory function. Here, authors use electrophysiological, optical and computational methods to investigate the structural changes that drive Kv7.4-channel opening, and how these are impaired by a deafness-causing mutation

Using a random regression model, the study shows there are varying genetic profiles that act on BMI from infancy to adolescence. Change in BMI across childhood is genetically correlated with several adult cardiometabolic traits.

Combining metabolic theory with global datasets, Li et al. show that root water content is a stronger predictor of root growth traits than the widely considered root nitrogen, better reflecting fast acquisition strategies and leaf–root alignment.

Recent work has revealed quantum coherent phase slips and current quantization in superconductors, phenomena dual to Cooper pair tunneling and voltage quantization. By combining the two effects, the authors demonstrate a Bloch transistor, a device that delivers quantized current and features a unique phase-locking mechanism.

ATF6α activation in human and preclinical models of hepatocellular carcinoma is significantly associated with an aggressive tumour phenotype characterized by reduced survival, glycolytic reprogramming and local immunosuppression.

This study shows that strain-stabilized interfacial polarization in metallic RuO₂/TiO₂ heterostructures modulates the work function by over 1 eV and the metallicity, establishing a new route to control the electronic properties of functional metals.

Visible-light-mediated intramolecular [2+2] cycloaddition of aza-1,6-dienes gives bridged, not fused, heterocycles, in violation of the ‘rule-of-five’, which dictates that five-membered rings are preferentially formed. This method allows a variety of bridged bicyclic scaffolds to be accessed, enabling drug-relevant properties to be readily tuned.

Many vascular‑disease risk loci lack defined causal genes. Here, the authors integrate functional genomics and CRISPR screens to identify genes influencing smooth muscle cell behaviour, validating roles for FES, BCAR1, CARF and SMARCA4, with Fes loss promoting atherosclerosis and hypertension.

In this work, authors use whole genome tracking in a neonatal intensive care unit to reveal a strong link between Staphylococcus aureus colonization and invasive infection, pinpointing critical new targets for infection prevention in high-risk infants.

Humans alter the daily timing of animal activity, potentially reshaping predator–prey interactions. This meta-analysis reveals that larger species tend to “lose” under human disturbance, with large predators overlapping less with their prey, and large prey overlapping more with their predators.

A technique called condense-seq has been developed to measure nucleosome condensability and used to show that mononucleosomes contain sufficient information to condense into large-scale compartments without requiring any external factors.

Therapies combining chemotherapy and immune checkpoint inhibitors have shown limited efficacy in patients with advanced pancreatic ductal adenocarcinoma (PDAC). Here the authors report the results of a pilot phase 1 trial of neoadjuvant modified Folfirinox plus nivolumab in borderline-resectable PDAC, including safety, efficacy and immunological correlates.

The authors realize two- and three-site Kitaev chains in semiconducting quantum dots coupled via superconductors and tune them to the sweet spot where zero-energy Majorana modes appear at the chain ends. To assess Majorana localization, they couple the system to an additional quantum dot.

Cryo-electron microscopy structures of three large ornate natural bacterial RNA molecules reveal their quaternary structures and intra- and intermolecular interactions that stabilize them.

Expression quantitative trait loci (eQTL) analysis in patients with inflammatory bowel disease identify potential target genes for IBD GWAS loci not readily detected in individuals without disease highlighting the importance disease-focused studies.

This study shows that in anxiety, circulating LPA16:0 produced by platelets inhibits adult hippocampal neurogenesis, resulting in increased susceptibility to stress and depression. These results support LPA16:0 as a potential therapeutic target for mood disorders.

Multiple myeloma involves alterations to T cell function, but mechanisms underlying disease evolution remain unclear. Here the authors find that, unlike solid cancers, multiple myeloma lacks exhausted T cells and is instead characterized by antigen-driven terminal memory T cell differentiation, which may be driven by tumour-intrinsic features including tumour burden and antigen-presentation gene expression.

Cobalt-based catalysts are regarded as a potentially cheaper alternative to platinum and chromium systems for the non-oxidative dehydrogenation of propane, although they often feature lower performance. Now mixed-valence Co^0/IIO_x clusters supported on silicalite-1 are identified as a competitive system for this reaction.

The CATS Net framework models how abstract concepts emerge from sensory experience. Aligning with human brain activity and enabling knowledge transfer, it provides a unified framework for understanding conceptual intelligence in both humans and AI.

The burden of dengue disease in infants has increased in Brazil over the last 25 years. Here, the authors analyse spatiotemporal heterogeneity in disease incidence to characterise the contribution of changing maternal immunity to infant dengue risk.

LC retention time prediction of peptides and their modifications is useful but is hindered by variations in experimental parameters. Here, the authors show how fine-tuning a deep learning model on a wide variety of experimental setups and modified peptides substantially improves predictions.

Meningiomas are common brain tumors with variable behavior. This study reveals high STING expression across multiple cell types in the meningioma microenvironment. STING agonism triggers tumor cell death via programmed necrosis and pyroptosis, enhancing survival in preclinical models.

Excess nitrogen fertilization in maize production harms the environment and society, yet farmers face yield risks when reducing inputs. Using field trials across the US Corn Belt, this study suggests that nitrogen rates can be reduced by 12–16% with minimal yield risk, reducing emissions and leaching.

Molecular glue degraders have consistently been discovered retrospectively, despite their increasing importance. Herein, a high-throughput approach is described that modifies existing ligands into molecular glue degraders.

Population-level analyses and in vitro experiments show that a specific genetic variant of cyclin D3 inhibits the growth of the malaria-causing parasite Plasmodium falciparum in erythrocytes, and suggest that its high frequency in Sardinia was driven by past endemic malaria.

T cell activation requires major metabolic adaptation. Here authors find that in mice and humans, expression of the NAD/H-synthesis enzyme nicotinamide riboside kinase 1 (NRK1) increases in CD4+ T cells upon activation, particularly within the cytoplasm, which impacts NADP/H and reactive oxygen species signalling, restraining activation and cytokine production while promoting CD4 + T cell survival during viral and fungal infections.

Most GWAS have focused on common variants or rare protein coding variants. Here, the authors interrogate the contribution of rare non-coding variants for anthropometric traits, identifying new genes associated with increased BMI and height.

Amundsen Sea records show warm Circumpolar Deep Water drove major West Antarctic Ice Sheet retreat from 18,000–10,000 years ago. Subsequent cooling stabilized the grounding line, indicating ocean heat—not atmospheric warming—controlled long-term WAIS change.

Histological analysis of the human pancreas provides insight into initiation and progression of type 1 diabetes (T1D). Here the authors utilize pancreatic tissue sections across different disease stages and apply whole slide imaging and digital pathology to identify endocrine cell composition, immune cell burden and spatial islet relationships in health and over the course of T1D.

Type 1 Innate Lymphoid cells (ILC1s) regulate the disease progression in murine models of acute myeloid leukaemia (AML). Here, the authors show that human ILC1s are impaired in patients with AML, and human umbilical cord blood-generated ILC1s can inhibit leukemia stem cell differentiation and limit AML development, suggesting a potential therapeutic approach.