The complex between BMP-2, a TGF-β family member, and its high affinity receptor provides new insights into the assembly of receptor complexes for members of the cystine-knot growth factor family. A novel proposal for the interaction between Flt3L and its receptor suggests a general scheme for the interaction of closely related receptor tyrosine kinases with structurally diverse ligands, including certain members of the TGF-β family.
- Christian Wiesmann
- Abraham M. de Vos