Nature Search

Genomics yields biological and phenotypic insights into bipolar disorder

Using multi-ancestry genome-wide association study and fine-mapping, 298 loci and 36 credible genes are identified in the aetiology of bipolar disorder.

Kevin S. O’Connell
Maria Koromina
Dan Siskind
Research22 Jan 2025
Nature

Volume: 639, P: 968-975
Mechanisms of Increased Susceptibility of Immature and Weaned Pigs to Escherichia coli Heat-Stable Enterotoxin

Adam G Mezoff
Nancy J Jensen
Mitchell B Cohen
Research01 May 1991
Pediatric Research

Volume: 29, P: 424-428
ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents

Carla Heise
Adam Sampson-Johannes
David H. Kirn
Research01 Jun 1997
Nature Medicine

Volume: 3, P: 639-645
The Effect of Blood Glucose Concentration on Postasphyxia Cerebral Hemodynamics in Newborn Lambs

Adam A Rosenberg
Elizabeth Murdaugh
Research01 May 1990
Pediatric Research

Volume: 27, P: 454-459
The clinical utility of integrative genomics in childhood cancer extends beyond targetable mutations

Shlien and colleagues report on 300 patients from the SickKids Cancer Sequencing program and identify clinically actionable variants in 56% of the patients by profiling somatic and germline data at multiple clinical time points.

Anita Villani
Scott Davidson
Adam Shlien
ResearchOpen Access30 Dec 2022
Nature Cancer

Volume: 4, P: 203-221
Germline TP53 mutations undergo copy number gain years prior to tumor diagnosis

Li-Fraumeni syndrome (LFS) is associated with pathogenic germline TP53 variants and predisposes patients to cancer; understanding the evolution and drivers of LFS-related tumours remains crucial. Here, the authors analyse 22 LFS tumours using whole-genome sequencing and reconstruct the evolution and timing of somatic driver alterations.

Nicholas Light
Mehdi Layeghifard
Adam Shlien
ResearchOpen Access05 Jan 2023
Nature Communications

Volume: 14, P: 1-12
Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology

Genome-wide association analyses of 41,917 bipolar disorder cases and 371,549 controls of European ancestry provide new insights into the etiology of this disorder and identify novel therapeutic leads and potential opportunities for drug repurposing.

Niamh Mullins
Andreas J. Forstner
Ole A. Andreassen
Research17 May 2021
Nature Genetics

Volume: 53, P: 817-829
A revised airway epithelial hierarchy includes CFTR-expressing ionocytes

Single-cell RNA sequencing analysis identifies cell types and lineages in airway epithelium, including the pulmonary ionocyte, a new cell type predominantly expressing the cystic fibrosis gene CFTR.

Daniel T. Montoro
Adam L. Haber
Jayaraj Rajagopal
Research01 Aug 2018
Nature

Volume: 560, P: 319-324
Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder

A genome-wide association study for attention deficit/hyperactivity disorder (ADHD) identifies 12 loci and implicates neurodevelopmental pathways and conserved regions of the genome as being involved in underlying ADHD biology.

Ditte Demontis
Raymond K. Walters
Benjamin M. Neale
Research26 Nov 2018
Nature Genetics

Volume: 51, P: 63-75
Functional imaging in adult and paediatric brain tumours

Are there any methods beyond MRI for brain tumours imaging? This Review by Andrew C. Peet and colleagues discusses the additional information that can be obtained by using functional imaging methods—such as diffusion imaging, perfusion imaging and magnetic resonance spectroscopy—and the challenges in determining the best way to incorporate these techniques into routine clinical practice.

Andrew C. Peet
Theodoros N. Arvanitis
Adam D. Waldman
Reviews13 Nov 2012
Nature Reviews Clinical Oncology

Volume: 9, P: 700-711
N-acetylneuraminic acid links immune exhaustion and accelerated memory deficit in diet-induced obese Alzheimer’s disease mouse model

Obesity and aging increase Alzheimer’s disease (AD) risk. Here, using an AD mouse model and high-fat diet, we suggest that immune exhaustion links the two risk factors, and identify a metabolite that can hasten immune dysfunction and memory deficit.

Stefano Suzzi
Tommaso Croese
Michal Schwartz
ResearchOpen Access09 Mar 2023
Nature Communications

Volume: 14, P: 1-19
Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics

An integrated analysis of over 100 single-cell and single-nucleus transcriptomics studies illustrates severe acute respiratory syndrome coronavirus 2 viral entry gene coexpression patterns across different human tissues, and shows association of age, smoking status and sex with viral entry gene expression in respiratory cell populations.

Christoph Muus
Malte D. Luecken
Xiaohui Zhang
Research02 Mar 2021
Nature Medicine

Volume: 27, P: 546-559
Quantitative imaging biomarkers in neuro-oncology

Conventional structural imaging provides limited information on tumor characterization and prognosis. Advances in neurosurgical techniques, radiotherapy planning and novel drug treatments for brain tumors have generated increasing need for reproducible, non-invasive, quantitative, imaging biomarkers. This Review discusses the role of physiological MRI and PET molecular imaging in understanding metabolic processes associated with tumor growth, blood flow and ultrastructure.

Adam D. Waldman
Alan Jackson
Jeremy H. Rees
Reviews23 Jun 2009
Nature Reviews Clinical Oncology

Volume: 6, P: 445-454
Comprehensive molecular portraits of human breast tumours

The Cancer Genome Atlas Network describe their multifaceted analyses of primary breast cancers, shedding light on breast cancer heterogeneity; although only three genes (TP53, PIK3CA and GATA3) are mutated at a frequency greater than 10% across all breast cancers, numerous subtype-associated and novel mutations were identified.

Daniel C. Koboldt
Robert S. Fulton
Jacqueline D. Palchik
ResearchOpen Access23 Sept 2012
Nature

Volume: 490, P: 61-70
GUCY2C signaling limits dopaminergic neuron vulnerability to toxic insults

Lara Cheslow
Matthew Byrne
Scott A. Waldman
ResearchOpen Access13 Apr 2024
npj Parkinson's Disease

Volume: 10, P: 1-16
Chimeric adenoviral (Ad5.F35) and listeria vector prime-boost immunization is safe and effective for cancer immunotherapy

John C. Flickinger Jr
Ross E. Staudt
Adam E. Snook
ResearchOpen Access23 Jun 2022
npj Vaccines

Volume: 7, P: 1-10
Blunted endogenous opioid release following an oral dexamphetamine challenge in abstinent alcohol-dependent individuals

Samuel Turton
James FM Myers
Anne Lingford-Hughes
ResearchOpen Access25 Jun 2018
Molecular Psychiatry

Volume: 25, P: 1749-1758
Blunted Endogenous Opioid Release Following an Oral Amphetamine Challenge in Pathological Gamblers

Inge Mick
Jim Myers
Anne R Lingford-Hughes
ResearchOpen Access10 Nov 2015
Neuropsychopharmacology

Volume: 41, P: 1742-1750
In Vivo Imaging of Cerebral Dopamine D3 Receptors in Alcoholism

David Erritzoe
Andri Tziortzi
Anne Lingford-Hughes
Research28 Jan 2014
Neuropsychopharmacology

Volume: 39, P: 1703-1712
Genome-wide association studies of coffee intake in UK/US participants of European ancestry uncover cohort-specific genetic associations

Hayley H. A. Thorpe
Pierre Fontanillas
Sandra Sanchez-Roige
Research11 Jun 2024
Neuropsychopharmacology

Volume: 49, P: 1609-1618
Dopamine Transporter 3′-UTR VNTR Genotype and ADHD: a Pharmaco-Behavioural Genetic Study with Methylphenidate

Ridha Joober
Natalie Grizenko
Marina Ter Stepanian
Research25 Oct 2006
Neuropsychopharmacology

Volume: 32, P: 1370-1376
CADM2 is implicated in impulsive personality and numerous other traits by genome- and phenome-wide association studies in humans and mice

Sandra Sanchez-Roige
Mariela V. Jennings
Abraham A. Palmer
ResearchOpen Access12 May 2023
Translational Psychiatry

Volume: 13, P: 1-11
Genome-wide association study of problematic opioid prescription use in 132,113 23andMe research participants of European ancestry

Sandra Sanchez-Roige
Pierre Fontanillas
Abraham A. Palmer
ResearchOpen Access02 Nov 2021
Molecular Psychiatry

Volume: 26, P: 6209-6217

Search

Genomics yields biological and phenotypic insights into bipolar disorder

Mechanisms of Increased Susceptibility of Immature and Weaned Pigs to Escherichia coli Heat-Stable Enterotoxin

ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents

The Effect of Blood Glucose Concentration on Postasphyxia Cerebral Hemodynamics in Newborn Lambs

The clinical utility of integrative genomics in childhood cancer extends beyond targetable mutations

Germline TP53 mutations undergo copy number gain years prior to tumor diagnosis

Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology

A revised airway epithelial hierarchy includes CFTR-expressing ionocytes

Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder

Functional imaging in adult and paediatric brain tumours

N-acetylneuraminic acid links immune exhaustion and accelerated memory deficit in diet-induced obese Alzheimer’s disease mouse model

Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics

Quantitative imaging biomarkers in neuro-oncology

Comprehensive molecular portraits of human breast tumours

GUCY2C signaling limits dopaminergic neuron vulnerability to toxic insults

Chimeric adenoviral (Ad5.F35) and listeria vector prime-boost immunization is safe and effective for cancer immunotherapy

Blunted endogenous opioid release following an oral dexamphetamine challenge in abstinent alcohol-dependent individuals

Blunted Endogenous Opioid Release Following an Oral Amphetamine Challenge in Pathological Gamblers

In Vivo Imaging of Cerebral Dopamine D3 Receptors in Alcoholism

Genome-wide association studies of coffee intake in UK/US participants of European ancestry uncover cohort-specific genetic associations

Dopamine Transporter 3′-UTR VNTR Genotype and ADHD: a Pharmaco-Behavioural Genetic Study with Methylphenidate

CADM2 is implicated in impulsive personality and numerous other traits by genome- and phenome-wide association studies in humans and mice

Genome-wide association study of problematic opioid prescription use in 132,113 23andMe research participants of European ancestry

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