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Native internally calibrated chromatin immunoprecipitation for quantitative studies of histone post-translational modifications

ICeChIP (internally calibrated ChIP) uses spiked-in, defined nucleosomal standards to overcome the pitfalls of traditional ChIP experiments, enabling the measurement of antibody specificity and the absolute measurement of histone modification density at genomic loci.

Adrian T. Grzybowski
Rohan N. Shah
Alexander J. Ruthenburg
Protocols13 Nov 2019
Nature Protocols

Volume: 14, P: 3275-3302
An eyecare foundation model for clinical assistance: a randomized controlled trial

Trained and validated on multimodal data from 14.5 million images from multicountry datasets, a foundation model is shown to increase diagnostic and referral accuracy of clinicians when used as an assistant in a trial involving 16 ophthalmologists and 668 patients.

Yilan Wu
Bo Qian
Bin Sheng
Research28 Aug 2025
Nature Medicine

P: 1-10
Epigenetic homogeneity in histone methylation underlies sperm programming for embryonic transcription

In addition to paternal genetic material, sperm contributes epigenetic information to the embryo to efficiently support development. Here, the authors demonstrate a homogeneous paternal contribution to epigenetic information via sperm-derived modified histone transmission to the developing vertebrate embryo.

Mami Oikawa
Angela Simeone
Jerome Jullien
ResearchOpen Access13 Jul 2020
Nature Communications

Volume: 11, P: 1-16
Guiding the HBO1 complex function through the JADE subunit

JADE is a subunit of human acetyltransferase complex HBO1 that is essential in transcriptional regulation. Gaurav et al. characterize the molecular mechanism by which JADE mediates genomic association and enzymatic and pathological activities of the HBO1 complex.

Nitika Gaurav
Akinori Kanai
Tatiana G. Kutateladze
Research06 Mar 2024
Nature Structural & Molecular Biology

Volume: 31, P: 1039-1049
NULISA: a proteomic liquid biopsy platform with attomolar sensitivity and high multiplexing

Unlocking the blood proteome requires exquisite sensitivity and multiplexing to detect low and high abundance proteins simultaneously. Here the authors describe a 200-plex immunoassay with attomolar sensitivity to detect important low abundance proteins in inflammatory diseases and COVID-19.

Wei Feng
Joanne C. Beer
Xiao-Jun Ma
ResearchOpen Access09 Nov 2023
Nature Communications

Volume: 14, P: 1-14
Author Correction: Complete biosynthesis of cannabinoids and their unnatural analogues in yeast

Xiaozhou Luo
Michael A. Reiter
Jay D. Keasling
Amendments and Corrections17 Mar 2020
Nature

Volume: 580, P: E2
Chromatin-enriched lncRNAs can act as cell-type specific activators of proximal gene transcription

Functional characterization of chromatin enriched lncRNAs (cheRNAs) reveals their role as cis-acting transcriptional activators that couple enhancers at sites of cheRNA synthesis to promoters of proximal target genes.

Michael S Werner
Matthew A Sullivan
Alexander J Ruthenburg
Research19 Jun 2017
Nature Structural & Molecular Biology

Volume: 24, P: 596-603
Complete biosynthesis of cannabinoids and their unnatural analogues in yeast

Genetic engineering of yeast enables the production of cannabinoids and cannabinoid analogues from the simple sugar galactose, without the need to cultivate Cannabis.

Xiaozhou Luo
Michael A. Reiter
Jay D. Keasling
Research27 Feb 2019
Nature

Volume: 567, P: 123-126

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