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Showing 1–5 of 5 results

Advanced filters: Author: Adrian Negrean Clear advanced filters

Synaptic basis of feature selectivity in hippocampal neurons

A temporally asymmetric synaptic plasticity kernel results from bidirectional modifications of synaptic weights around the induction of a place field.

Kevin C. Gonzalez
Adrian Negrean
Attila Losonczy
Research18 Dec 2024
Nature

Volume: 637, P: 1152-1160
Visually guided in vivo single-cell electroporation for monitoring and manipulating mammalian hippocampal neurons

An in vivo single-cell electroporation method enables the delivery of plasmids selectively to individual pyramidal neurons in the mouse dorsal hippocampus, guided by two-photon imaging.

Kevin C. Gonzalez
Asako Noguchi
Attila Losonczy
Protocols10 Feb 2025
Nature Protocols

Volume: 20, P: 1468-1484
Functional architecture of intracellular oscillations in hippocampal dendrites

Neurons receive their input in three dimensions via their dendrites, but how electrical activity in dendrites is organized is unknown. Here, the authors work out the distinct rules that govern activity across this 3D structure in different brain states.

Zhenrui Liao
Kevin C. Gonzalez
Adrian Negrean
ResearchOpen Access26 Jul 2024
Nature Communications

Volume: 15, P: 1-16
A positively tuned voltage indicator for extended electrical recordings in the brain

The ASAP4 family of genetically encoded voltage indicators allows recording of action potentials and subthreshold activity with either one- or two-photon microscopy over extended periods of time.

S. Wenceslao Evans
Dong-Qing Shi
Michael Z. Lin
Research06 Jul 2023
Nature Methods

Volume: 20, P: 1104-1113
Local circuit amplification of spatial selectivity in the hippocampus

Single-cell tracing and optogenetics manipulation in mice are used to show how spatial tuning of individual pyramidal cells in CA1 can propagate to and be amplified by their local subnetwork of neurons.

Tristan Geiller
Sadra Sadeh
Attila Losonczy
Research01 Dec 2021
Nature

Volume: 601, P: 105-109