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Showing 1–2 of 2 results
Advanced filters: Author: Aiyun Wen Clear advanced filters

  • Endothelial cell (EC) dysfunction and inflammation contribute to plaque destabilization in atherosclerosis, increasing the risk of thrombotic events. Here, the authors show that epsin promotes EC inflammation via a mechanism involving IP3R1 degradation, and that deletion of epsin in the endothelium prevents EC dysfunctoin and atherosclerosis in mice.

    • Yunzhou Dong
    • Yang Lee
    • Hong Chen
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16

  • Weeden et al. use a method called FORCE to deliver oligonucleotides to muscle and evaluate the platform’s utility in models of myotonic dystrophy. An antisense oligonucleotide targeting DMPK is guided to muscle tissue with an antibody fragment and beneficial results are seen in mouse models of disease and cynomolgus monkey.

    • Timothy Weeden
    • Tyler Picariello
    • Stefano Zanotti
    ResearchOpen Access
    Communications Medicine
    Volume: 5, P: 1-18