In order to find a therapeutic target for triple negative breast cancer (TNBC), the authors performed a siRNA screening and identified the cell cycle regulator polo-like kinase 1 (PLK) as an essential molecule for survival of TNBC cells. PLK1 is highly expressed in TNBC tissue and inhibition of PLK1 triggers apoptosis in a series of TNBC cell lines.
- Ai Ueda
- Keiki Oikawa
- Kohsuke Kanekura
