Nature Search

Rational modification of enzyme catalysis by engineering surface charge

Alan J. Russell
Alan R. Fersht
Research06 Aug 1987
Nature

Volume: 328, P: 496-500
Acceleration of Growth Rate in Growth Hormone-Deficient Children Treated with Human Growth Hormone-Releasing Hormone

Michael O Thorner
Alan D Rogol
Charles Brook
Research01 Aug 1988
Pediatric Research

Volume: 24, P: 145-151
Addendum: Synthesis and reactivity of precolibactin 886

Alan R. Healy
Kevin M. Wernke
Seth B. Herzon
Amendments and Corrections12 Nov 2019
Nature Chemistry

Volume: 11, P: 1167
Predicting opioid consumption after surgical discharge: a multinational derivation and validation study using a foundation model

Chris Varghese
Luke Peters
Caroline Reinke
ResearchOpen Access26 Aug 2025
npj Digital Medicine

Volume: 8, P: 1-16
Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast–ovarian cancer susceptibility locus

A region on chromosome 19p13 is associated with the risk of developing ovarian and breast cancer. Here, the authors genotyped SNPs in this region in thousands of breast and ovarian cancer patients and identified SNPs associated with three genes, which were analysed with functional studies.

Kate Lawrenson
Siddhartha Kar
Simon A. Gayther
ResearchOpen Access07 Sept 2016
Nature Communications

Volume: 7, P: 1-22
Single-cell RNA sequencing reveals time- and sex-specific responses of mouse spinal cord microglia to peripheral nerve injury and links ApoE to chronic pain

Microglia subpopulations may differentially contribute to pain. Here, the authors show that peripheral nerve injury induces time- and sex-specific transcriptional changes in mouse spinal cord microglia subpopulations and that ApoE is linked to neuropathic pain hypersensitivity in mice and humans.

Shannon Tansley
Sonali Uttam
Arkady Khoutorsky
ResearchOpen Access11 Feb 2022
Nature Communications

Volume: 13, P: 1-16
A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage

Activation of the tumor suppressor p53 is a promising approach in cancer therapy. Here, the authors discover a series of small molecule dihydroorotate dehydrogenase (DHODH) inhibitors that increase p53 synthesis and reduce tumor growth in synergy with the common mdm2 inhibitor nutlin3.

Marcus J. G. W. Ladds
Ingeborg M. M. van Leeuwen
Sonia Laín
ResearchOpen Access16 Mar 2018
Nature Communications

Volume: 9, P: 1-14
Mutations associated with neuropsychiatric conditions delineate functional brain connectivity dimensions contributing to autism and schizophrenia

The impact of neurodevelopmental mutations on functional brain connectivity is poorly understood. Here the authors identify thalamo-sensorimotor dysconnectivity dimensions shared across 16p11.2 and 22q11.2 copy number variants, autism and schizophrenia, but not ADHD.

Clara A. Moreau
Sebastian G. W. Urchs
Sebastien Jacquemont
ResearchOpen Access19 Oct 2020
Nature Communications

Volume: 11, P: 1-12
Human lifespan changes in the brain’s functional connectome

Sun et al. report human lifespan changes in the brain’s functional connectome in 33,250 individuals, which highlights critical growth milestones and distinct maturation patterns and offers a normative reference for development, aging and diseases.

Lianglong Sun
Tengda Zhao
Yong He
Research03 Apr 2025
Nature Neuroscience

Volume: 28, P: 891-901
Synthesis and reactivity of precolibactin 886

Precolibactin 886 is a complex microbiome-derived metabolite implicated in colorectal cancer and produced by the clb gene cluster. A chemical synthesis and analysis of precolibactin 886 is reported which shows that its biosynthetic precursor degrades to other known clb metabolites. The data also provide insights into the structures and reactivity of advanced clb products.

Alan R. Healy
Kevin M. Wernke
Seth B. Herzon
Research23 Sept 2019
Nature Chemistry

Volume: 11, P: 890-898
CHLAMYDIA TRACHOMATIS AND NESSERIA GONORRHOEAE INCIDENCE IN FEMALE ADOLESCENTS

Alan Figelman
John Keiser
Patrick Healy
Research01 Apr 1984
Pediatric Research

Volume: 18, P: 97
Publisher Correction: A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage

Marcus J. G. W. Ladds
Ingeborg M. M. van Leeuwen
Sonia Laín
Amendments and CorrectionsOpen Access18 Aug 2023
Nature Communications

Volume: 14, P: 1-3
p53, mutation frequency and apoptosis in the murine small intestine

Alan R Clarke
Louise A Howard
Douglas J Winton
Research01 May 1997
Oncogene

Volume: 14, P: 2015-2018
Altered Growth Hormone Secretory Dynamics in Prepubertal Males with Constitutional Delay of Growth

James R Kerrigan
Paul M Martha JR.
Alan D Rogol
Research01 Mar 1993
Pediatric Research

Volume: 33, P: 278-283
Genome sequence, comparative analysis and haplotype structure of the domestic dog

Kerstin Lindblad-Toh
Claire M Wade
Eric S. Lander
Research08 Dec 2005
Nature

Volume: 438, P: 803-819
Orphan receptor IL-17RD regulates Toll-like receptor signalling via SEFIR/TIR interactions

Toll-like receptors detect conserved microbial features to initiate host defence and are tightly regulated. Here the authors show that the orphan receptor interleukin-17 receptor D negatively regulates signalling downstream of Toll-like receptors to prevent excessive inflammation.

Mark Mellett
Paola Atzei
Paul N. Moynagh
Research26 Mar 2015
Nature Communications

Volume: 6, P: 1-15
Publisher Correction: A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage

Marcus J. G. W. Ladds
Ingeborg M. M. van Leeuwen
Sonia Laín
Amendments and CorrectionsOpen Access22 May 2018
Nature Communications

Volume: 9, P: 1-2
Observed controls on resilience of groundwater to climate variability in sub-Saharan Africa

Analysis of multidecadal hydrograph and precipitation data for sub-Saharan Africa shows a complex relationship between groundwater recharge and precipitation, and that a drier climate does not necessarily mean less recharge.

Mark O. Cuthbert
Richard G. Taylor
Neno Kukuric
Research07 Aug 2019
Nature

Volume: 572, P: 230-234
Genome-wide meta-analyses identify multiple loci associated with smoking behavior

The Tobacco and Genetics Consortium report meta-analyses of several smoking phenotypes across 16 cohorts including 74,053 individuals. They identify three loci associated with cigarettes smoked per day.

Helena Furberg
YunJung Kim
Patrick F Sullivan
Research25 Apr 2010
Nature Genetics

Volume: 42, P: 441-447
Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage

The International Stem Cell Initiative compares 125 ethnically diverse human embryonic stem cell lines at early and late passage. Data on karotype, single-nucleotide polymorphisms and methylation shed light on how the cells adapt to long-term culture.

Katherine Amps
Peter W Andrews
Qi Zhou
Research27 Nov 2011
Nature Biotechnology

Volume: 29, P: 1132-1144
Structural insights into selective small molecule activation of PKG1α

Structural characterization and modeling of cGMP‐dependent protein kinase I‐α (PKG1α) with a small molecule activator suggest the activation mechanism for the PKG1α homodimer.

Essam Metwally
Victor Mak
Thierry O. Fischmann
ResearchOpen Access31 Jul 2023
Communications Biology

Volume: 6, P: 1-13
Inherited duplications of PPP2R3B predispose to nevi and melanoma via a C21orf91-driven proliferative phenotype

Satyamaanasa Polubothu
Davide Zecchin
Veronica A. Kinsler
ResearchOpen Access18 Jun 2021
Genetics in Medicine

Volume: 23, P: 1636-1647
Paclitaxel sensitivity in relation to ABCB1 expression, efflux and single nucleotide polymorphisms in ovarian cancer

Bo Gao
Amanda Russell
Anna deFazio
ResearchOpen Access09 May 2014
Scientific Reports

Volume: 4, P: 1-9
Polydipsia in Chronic Psychiatric Patients: Therapeutic Trials of Clonidine and Enalapril

Robert M Greendyke
Alan J Bernhardt
Kathleen S Lewandowski
Research01 Apr 1998
Neuropsychopharmacology

Volume: 18, P: 272-281
The impact of immediate breast reconstruction on the time to delivery of adjuvant therapy: the iBRA-2 study

Rachel L O’Connell
Tim Rattay
Mohammed Mustafa
ResearchOpen Access29 Mar 2019
British Journal of Cancer

Volume: 120, P: 883-895

Search

Rational modification of enzyme catalysis by engineering surface charge

Acceleration of Growth Rate in Growth Hormone-Deficient Children Treated with Human Growth Hormone-Releasing Hormone

Addendum: Synthesis and reactivity of precolibactin 886

Predicting opioid consumption after surgical discharge: a multinational derivation and validation study using a foundation model

Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast–ovarian cancer susceptibility locus

Single-cell RNA sequencing reveals time- and sex-specific responses of mouse spinal cord microglia to peripheral nerve injury and links ApoE to chronic pain

A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage

Mutations associated with neuropsychiatric conditions delineate functional brain connectivity dimensions contributing to autism and schizophrenia

Human lifespan changes in the brain’s functional connectome

Synthesis and reactivity of precolibactin 886

CHLAMYDIA TRACHOMATIS AND NESSERIA GONORRHOEAE INCIDENCE IN FEMALE ADOLESCENTS

Publisher Correction: A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage

p53, mutation frequency and apoptosis in the murine small intestine

Altered Growth Hormone Secretory Dynamics in Prepubertal Males with Constitutional Delay of Growth

Genome sequence, comparative analysis and haplotype structure of the domestic dog

Orphan receptor IL-17RD regulates Toll-like receptor signalling via SEFIR/TIR interactions

Publisher Correction: A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage

Observed controls on resilience of groundwater to climate variability in sub-Saharan Africa

Genome-wide meta-analyses identify multiple loci associated with smoking behavior

Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage

Structural insights into selective small molecule activation of PKG1α

Inherited duplications of PPP2R3B predispose to nevi and melanoma via a C21orf91-driven proliferative phenotype

Paclitaxel sensitivity in relation to ABCB1 expression, efflux and single nucleotide polymorphisms in ovarian cancer

Polydipsia in Chronic Psychiatric Patients: Therapeutic Trials of Clonidine and Enalapril

The impact of immediate breast reconstruction on the time to delivery of adjuvant therapy: the iBRA-2 study

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