Nature Search

Correction: Corrigendum: Assignment of protein function in the postgenomic era

Alan Saghatelian
Benjamin F Cravatt
Amendments and Corrections01 Sept 2005
Nature Chemical Biology

Volume: 1, P: 233
Rp3: Ribosome profiling-assisted proteogenomics improves coverage and confidence during microprotein discovery

Small genes have been ignored for years in the genome of every organism due to experimental and computational limitations. Here, the authors describe a computational tool named Rp3 that integrates two high throughput approaches to identify microproteins encoded by these short genes.

Eduardo Vieira de Souza
Angie L. Bookout
Alan Saghatelian
ResearchOpen Access09 Aug 2024
Nature Communications

Volume: 15, P: 1-14
Macrophage VLDL receptor promotes PAFAH secretion in mother's milk and suppresses systemic inflammation in nursing neonates

Mother's milk contains a number of protective factors, such as the anti-inflammatory enzyme PAFAH. Here, Duet al. show that the VLDL receptor protects nursing newborns from systemic inflammation by maintaining secretion of PAFAH from maternal macrophages into mother's milk.

Yang Du
Marie Yang
Yihong Wan
Research21 Aug 2012
Nature Communications

Volume: 3, P: 1-8
ATGL is a biosynthetic enzyme for fatty acid esters of hydroxy fatty acids

A study in mammals identifies a new role for adipose triglyceride lipase in catalysing the esterification of hydroxyl fatty acids to produce biologically active fatty acid esters of hydroxy fatty acids.

Rucha Patel
Anna Santoro
Barbara B. Kahn
ResearchOpen Access08 Jun 2022
Nature

Volume: 606, P: 968-975
Peptidase substrates via global peptide profiling

Debarati M Tagore
Whitney M Nolte
Alan Saghatelian
Research16 Nov 2008
Nature Chemical Biology

Volume: 5, P: 23-25
Translon: a single term for translated regions

Michał I. Świrski
Jack A. S. Tierney
Pavel V. Baranov
Correspondence01 Sept 2025
Nature Methods

Volume: 22, P: 2002-2006
Discovering ligand-receptor interactions

A new probe identifies cell-surface receptors bound by known ligands.

Sarah A Slavoff
Alan Saghatelian
News & Views10 Oct 2012
Nature Biotechnology

Volume: 30, P: 959-961
A class of anti-inflammatory lipids decrease with aging in the central nervous system

Tan et al. reveal that a class of lipids, 3-sulfogalactosyl diacylglycerols, decrease in the central nervous system with aging. 3-sulfogalactosyl diacylglycerols are present in the human brain and suppress inflammation suggesting these lipids may play a role in age-related diseases and inflammation.

Dan Tan
Srihari Konduri
Alan Saghatelian
Research20 Oct 2022
Nature Chemical Biology

Volume: 19, P: 187-197
Accurate annotation of human protein-coding small open reading frames

An improved workflow combining de novo transcriptome assembly and Ribo-seq validated by cellular antigen display is developed to maximize small peptide discovery, leading to identification of thousands of unannotated protein-coding smORFs.

Thomas F. Martinez
Qian Chu
Alan Saghatelian
Research09 Dec 2019
Nature Chemical Biology

Volume: 16, P: 458-468
Regulation of the ER stress response by a mitochondrial microprotein

Cells trigger an unfolded protein response (UPR) in the endoplasmic reticulum, but its regulation by mitochondria is unclear. Here, the authors report a 54-residue microprotein PIGBOS that participates in inter-organelle contact between the endoplasmic reticulum and the mitochondria and may regulate UPR.

Qian Chu
Thomas F. Martinez
Alan Saghatelian
ResearchOpen Access25 Oct 2019
Nature Communications

Volume: 10, P: 1-13
AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs

Activity-based protein profiling identifies AIG1 and ADTRPP as transmembrane threonine hydrolases with substrates that include several fatty acid esters of hydroxyl fatty acids (FAHFAs). New inhibitors of these enzymes inhibit FAHFA hydrolysis.

William H Parsons
Matthew J Kolar
Benjamin F Cravatt
Research28 Mar 2016
Nature Chemical Biology

Volume: 12, P: 367-372
Autoantibody mimicry of hormone action at the thyrotropin receptor

Cryo-electron microscopy structures of the thyrotropin receptor reveal the basis for the activation of the receptor by autoantibodies in patients with Graves’ disease.

Bryan Faust
Christian B. Billesbølle
Aashish Manglik
Research08 Aug 2022
Nature

Volume: 609, P: 846-853
Identification of protein pheromones that promote aggressive behaviour

The protein component of the major urinary protein complex is identified as a potential pheromone ligand mediating male–male aggression via the accessory olfactory pathway.

Pablo Chamero
Tobias F. Marton
Lisa Stowers
Research06 Dec 2007
Nature

Volume: 450, P: 899-902
Target discovery in small-molecule cell-based screens by in situ proteome reactivity profiling

Michael J Evans
Alan Saghatelian
Benjamin F Cravatt
Research02 Oct 2005
Nature Biotechnology

Volume: 23, P: 1303-1307
A chiroselective peptide replicator

Alan Saghatelian
Yohei Yokobayashi
M. Reza Ghadiri
Research15 Feb 2001
Nature

Volume: 409, P: 797-801
Inflammation causes insulin resistance in mice via interferon regulatory factor 3 (IRF3)-mediated reduction in FAHFA levels

Inflammation promotes insulin resistance in adipocytes, but the mechanism is unclear. Here, the authors show that the inflammatory transcription factor IRF3 drives expression of AIG1, which encodes a hydrolase that breaks down a class of insulin-sensitizing lipid called FAHFAs.

Shuai Yan
Anna Santoro
Evan D. Rosen
ResearchOpen Access30 May 2024
Nature Communications

Volume: 15, P: 1-19
The TINCR ubiquitin-like microprotein is a tumor suppressor in squamous cell carcinoma

TINCR encodes a p53-regulated ubiquitin-like microprotein expressed in stratified epithelia. Tincr loss promotes UVB-induced skin carcinogenesis in mice and deletions and mutations in human squamous cell carcinoma support a tumor suppressor role.

Lucia Morgado-Palacin
Jessie A. Brown
Adolfo A. Ferrando
ResearchOpen Access10 Mar 2023
Nature Communications

Volume: 14, P: 1-14
Peptidomic discovery of short open reading frame–encoded peptides in human cells

The human genome contains stretches of DNA sequence with unknown function. Peptidomics coupled to RNA-Seq now reveals a class of short open reading frames in human genomes that are translated into small peptides.

Sarah A Slavoff
Andrew J Mitchell
Alan Saghatelian
Research18 Nov 2012
Nature Chemical Biology

Volume: 9, P: 59-64
A fast-acting lipid checkpoint in G1 prevents mitotic defects

Lipid synthesis increases during the cell cycle to ensure sufficient membrane mass. Here, authors identify a lipid checkpoint in G1 phase that prevents cells from starting the cell cycle if lipid synthesis is low, thereby preventing mitotic defects.

Marielle S. Köberlin
Yilin Fan
Tobias Meyer
ResearchOpen Access18 Mar 2024
Nature Communications

Volume: 15, P: 1-17
Serine restriction alters sphingolipid diversity to constrain tumour growth

In xenograft tumour models in mice, modulation of dietary serine, serine palmitoyltransferase or phosphoglycerate dehydrogenase activity enables control of the endogenous synthesis of deoxysphingolipids, sensitizing the tumours to metabolic stress and slowing their progression.

Thangaselvam Muthusamy
Thekla Cordes
Christian M. Metallo
Research12 Aug 2020
Nature

Volume: 586, P: 790-795
Directed remodeling of the mouse gut microbiome inhibits the development of atherosclerosis

Gut microbiome composition is remodeled using small peptides.

Poshen B. Chen
Audrey S. Black
M. Reza Ghadiri
Research15 Jun 2020
Nature Biotechnology

Volume: 38, P: 1288-1297
Large-scale proteogenomics characterization of microproteins in Mycobacterium tuberculosis

Eduardo V. de Souza
Pedro F. Dalberto
Cristiano V. Bizarro
ResearchOpen Access28 Dec 2024
Scientific Reports

Volume: 14, P: 1-17
Antibiotic-induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolism

Antibiotic-induced microbiome depletion is one of the most common approaches to modulate the gut microbiome. Here the authors demonstrate that it affects gut homeostasis and glucose metabolism by decreasing luminal short chain fatty acids and leading to a shift of energy utilization by colonocytes.

Amir Zarrinpar
Amandine Chaix
Satchidananda Panda
ResearchOpen Access20 Jul 2018
Nature Communications

Volume: 9, P: 1-13
An alternative pluripotent state confers interspecies chimaeric competency

A previously unknown type of stem cell that can engraft in specific regions of the mouse epiblast is described; these region-selective pluripotent stem cells display notable intra- and inter-specific chimaera competency and will help to further our understanding of mammalian development.

Jun Wu
Daiji Okamura
Juan Carlos Izpisua Belmonte
Research06 May 2015
Nature

Volume: 521, P: 316-321
Revealing disease-associated pathways by network integration of untargeted metabolomics

A network-based method and computational tool, PIUMet, reveals disease-associated molecular pathways from untargeted metabolomics data without requiring mass-spectral feature identification.

Leila Pirhaji
Pamela Milani
Ernest Fraenkel
Research01 Aug 2016
Nature Methods

Volume: 13, P: 770-776
Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models

An allosteric inhibitor of acetyl-CoA carboxylase reveals a metabolic liability of non-small-cell lung cancer and slows tumor growth alone and in combination with chemotherapy in mouse models.

Robert U Svensson
Seth J Parker
Reuben J Shaw
Research19 Sept 2016
Nature Medicine

Volume: 22, P: 1108-1119
A human microprotein that interacts with the mRNA decapping complex

Mass-spectrometry-based proteomics led to the identification of NoBody, a microprotein translated from LINC01420 RNA, which interacts with enhancer of decapping 4 (EDC4) and negatively regulates 5′-to-3′ mRNA decay.

Nadia G D'Lima
Jiao Ma
Sarah A Slavoff
Research05 Dec 2016
Nature Chemical Biology

Volume: 13, P: 174-180
Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones

The discovery of a selective, physiologically active inhibitor of insulin-degrading enzyme (IDE) illuminates the therapeutic potential of IDE inhibitors for the treatment of diabetes and reveals that IDE regulates in vivo glucagon and amylin, in addition to insulin.

Juan Pablo Maianti
Amanda McFedries
David R. Liu
Research21 May 2014
Nature

Volume: 511, P: 94-98
The measurement, regulation and biological activity of FAHFAs

This Review underscores the pivotal role of chemical biology in the discovery and characterization of fatty acid esters of hydroxy fatty acids, bioactive lipids linked to metabolic health and inflammation.

Dan Tan
Alan Saghatelian
Reviews28 Jan 2025
Nature Chemical Biology

Volume: 21, P: 796-806
Pharmacological activation of REV-ERBs is lethal in cancer and oncogene-induced senescence

REV-ERBs, nuclear hormone receptors that regulate transcription as part of the circadian clock cell machinery, inhibit autophagy and lipogenesis in premalignant and malignant cells and impair tumour growth in vivo.

Gabriele Sulli
Amy Rommel
Satchidananda Panda
Research10 Jan 2018
Nature

Volume: 553, P: 351-355
mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide

The polypeptide SPAR is encoded by a long non-coding RNA, localizes to the late endosome and lysosome, and regulates muscle regeneration by inhibiting mTORC1.

Akinobu Matsumoto
Alessandra Pasut
Pier Paolo Pandolfi
Research26 Dec 2016
Nature

Volume: 541, P: 228-232
Regulation of DNA repair pathway choice in S and G2 phases by the NHEJ inhibitor CYREN

CYREN is a direct inhibitor of classical non-homologous end joining that promotes error-free repair by homologous recombination during the S and G2 phases of the cell cycle.

Nausica Arnoult
Adriana Correia
Jan Karlseder
Research28 Sept 2017
Nature

Volume: 549, P: 548-552
A diurnal serum lipid integrates hepatic lipogenesis and peripheral fatty acid use

How the liver communicates with peripheral tissues to achieve metabolic homeostasis is poorly defined; here the authors show that the nuclear hormone receptor PPARδ regulates de novo lipogenesis in the liver and orchestrates fat use by muscle via a circulating lipid.

Sihao Liu
Jonathan D. Brown
Chih-Hao Lee
Research23 Oct 2013
Nature

Volume: 502, P: 550-554
Synthesis of chemically edited derivatives of the endogenous regulator of inflammation 9-PAHSA

Huijing Wang
Tina Chang
Dionicio Siegel
Research15 Apr 2019
The Journal of Antibiotics

Volume: 72, P: 498-506
The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR

Ageing in the worm Caenorhabditis elegans is shown to be delayed by supplementation with α-ketoglutarate, an effect that is probably mediated by ATP synthase—which is identified as a direct target of α-ketoglutarate—and target of rapamycin (TOR).

Randall M. Chin
Xudong Fu
Jing Huang
Research14 May 2014
Nature

Volume: 510, P: 397-401
Analysis of the proteolysis of bioactive peptides using a peptidomics approach

Yun-Gon Kim
Anna Mari Lone
Alan Saghatelian
Protocols15 Aug 2013
Nature Protocols

Volume: 8, P: 1730-1742
How many human proteoforms are there?

Ruedi Aebersold
Jeffrey N Agar
Bing Zhang
Reviews14 Feb 2018
Nature Chemical Biology

Volume: 14, P: 206-214
Discovery and characterization of smORF-encoded bioactive polypeptides

Alan Saghatelian
Juan Pablo Couso
Reviews17 Nov 2015
Nature Chemical Biology

Volume: 11, P: 909-916
Standardized annotation of translated open reading frames

Jonathan M. Mudge
Jorge Ruiz-Orera
Sebastiaan van Heesch
Correspondence13 Jul 2022
Nature Biotechnology

Volume: 40, P: 994-999
Assignment of protein function in the postgenomic era

Alan Saghatelian
Benjamin F Cravatt
Reviews01 Aug 2005
Nature Chemical Biology

Volume: 1, P: 130-142
Mitochondrial DNA variation in Alzheimer’s disease reveals a unique microprotein called SHMOOSE

Brendan Miller
Su-Jeong Kim
Pinchas Cohen
Research21 Sept 2022
Molecular Psychiatry

Volume: 28, P: 1813-1826
Blocking Zika virus vertical transmission

Pinar Mesci
Angela Macia
Alysson R. Muotri
ResearchOpen Access19 Jan 2018
Scientific Reports

Volume: 8, P: 1-13
Overexpressing the novel autocrine/endocrine adipokine WISP2 induces hyperplasia of the heart, white and brown adipose tissues and prevents insulin resistance

John R. Grünberg
Jenny M. Hoffmann
Ulf Smith
ResearchOpen Access27 Feb 2017
Scientific Reports

Volume: 7, P: 1-15
A LC-MS–based workflow for measurement of branched fatty acid esters of hydroxy fatty acids

Branched fatty acid esters of hydroxy fatty acids (FAHFAs) are a recently discovered class of biological lipids. This protocol describes their extraction from serum and tissue samples, followed by enrichment and analysis by LC-MS.

Tejia Zhang
Shili Chen
Alan Saghatelian
Protocols17 Mar 2016
Nature Protocols

Volume: 11, P: 747-763
Correction: Mitochondrial DNA variation in Alzheimer’s disease reveals a unique microprotein called SHMOOSE

Brendan Miller
Su-Jeong Kim
Pinchas Cohen
Amendments and Corrections20 Jan 2023
Molecular Psychiatry

Volume: 28, P: 1827
Author Correction: Blocking Zika virus vertical transmission

Pinar Mesci
Angela Macia
Alysson R. Muotri
Amendments and CorrectionsOpen Access05 Jun 2018
Scientific Reports

Volume: 8, P: 1

Search

Filter By:

Search

Quick links