Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Correspondence
  • Published:

Translon: a single term for translated regions

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Open reading frames (ORFs) and translated regions.

References

  1. Mueller, P. P. & Hinnebusch, A. G. Cell 45, 201–207 (1986).

    Article  CAS  PubMed  Google Scholar 

  2. Werner, M., Feller, A., Messenguy, F. & Piérard, A. Cell 49, 805–813 (1987).

    Article  CAS  PubMed  Google Scholar 

  3. Andreev, D. E. et al. Genome Biol 23, 111 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Baclaocos, J. et al. J. Mol. Biol. 431, 4381–4407 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Zinshteyn, B. & Green, R. Science 354, 1106 (2016).

    Article  CAS  PubMed  Google Scholar 

  6. Lobanov, A. V. et al. Nat. Struct. Mol. Biol. 24, 61–68 (2017).

    Article  CAS  PubMed  Google Scholar 

  7. Aspden, J. L., Wallace, E. W. J. & Whiffin, N. Cell Genomics 3, 100296 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Goel, S. C. Nature 245, 397 (1973).

    Article  Google Scholar 

  9. Gilbert, W. Nature 271, 501 (1978).

    Article  CAS  PubMed  Google Scholar 

  10. Nosek, J., Tomaska, L., Burger, G. & Lang, B. F. Trends Genet 31, 187–194 (2015).

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

We wish to thank the participants of the 2024 EMBO Workshop “Recoding and the diversity of genetic decoding” and the 2024 Dagstuhl Seminar “Deep Learning for RNA Regulation and Multidimensional Transcriptomics,” as well as the members of TransCODE consortium and TRANSLACORE network (supported by COST action CA21154) for invaluable discussions that led to the development of this proposal.

Author information

Authors and Affiliations

Authors

Consortia

Contributions

M.I.Ś., J.A.S.T., E.V. and P.V.B. developed the concept and drafted the Correspondence. M.M.A., D.E.A., J.L.A., J.F.A., M.B.-S., M.J.B., S.B., K.B.-L., M. Borodovsky, I.B., M. Brook, M.A.B., J.M.B., N.C., L. Calviello, A.-R.C., J.H.D.C., C.C., K.Y.C., Y.C., S.C., J.S.C., P.L.C., J.C., L. Cooley, E.D., K.D., J.-J.D., C.D., R.D., J.D.D., S.E.D., O.A.D., C.M.D., S.M.E., P.J.F., P.F., I.F.-M., A.E.F., D.G., F.G., M.S.G., N.K.G., R.G., C.H.H., Y.-M.H., N.H., Z.I., P.I., S.I., R.J., A.J., M.J., I.J., M.K., J.S.K., A.V.K., E.V.K., A.A.K., J.K., I.V.K., L.K., D.L.J.L., O.L., G.L., J.L, M. Mariotti, E.S.M.-U., T.F.M., A.M., J. McManus, J. Medenbach, S.V.M., G.M., C.M., M. Mikl, W.A.M., O.M., O.N., D.D.N., J.N., S.O., P.O., M.P., D.D.P., L.R., D.R., X.R., M.P.R., J.R.-O., A.S., S.L.S., L.A.S., C.S., P.V.S., P.S., N. Shirokikh, S.A.S., N. Sonenberg, T.J.S., R.J.S., T. Tamm, M.T., I.T., M.L.T., T. Tuller, I.U., L.S.V., P.V.D., G.V., J.A.V., C.V., E.W.J.W., J.S.W., E.W., N.W., D.N.W., Z.X., J.W.Y., M.M.Y., C.-H.Y., V.Y. and B.Z. critically discussed the concept and/or edited the manuscript at different stages of its development.

Corresponding authors

Correspondence to Michał I. Świrski, Jack A. S. Tierney, Eivind Valen or Pavel V. Baranov.

Ethics declarations

Competing interests

A.-R.C. is on the scientific advisory board of ProFound Therapeutics. G.L. and P.V.B. are co-founders and shareholders of Eirnabio Ltd. The remaining authors declare no competing interests.

Peer review

Peer review information

Nature Methods thanks the anonymous reviewers for their contribution to the peer review of this work.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Świrski, M.I., Tierney, J.A.S., Albà, M.M. et al. Translon: a single term for translated regions. Nat Methods (2025). https://doi.org/10.1038/s41592-025-02810-3

Download citation

  • Published:

  • DOI: https://doi.org/10.1038/s41592-025-02810-3

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing