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These scientists prioritized their replies to letters in the same way that people rate their e-mails today.

Glioblastoma—the deadliest form of brain cancer—alters the calvarial bone and its marrow components, pushing it toward producing more myeloid cells and contributing to an immunosuppressive environment.

Haematopoietic stem cell numbers are restricted at both systemic and local levels.

Perturbing a physical system, for example, picking a guitar string to make it vibrate, tells a lot about its intrinsic properties. Here the authors show that such concepts hold even for quantum gases of light, which respond to a perturbation with the same dynamics as they fluctuate on their own.

Ramsey interferometers are used to measure minute energy shifts, but they are usually only applied to simple, non-interacting ensembles. Here, the authors demonstrate a two-pulse Ramsey-type interferometer built on the motional states of an interacting Bose–Einstein condensate using optimal control.

The quantum mechanical concept of ‘steering’ refers to the feasibility of one system to nonlocally affect, or steer, another system’s states through local measurements. Multipartite steering is now demonstrated in a programmable optical network.

LRP8, an apolipoprotein E and reelin receptor with high expression in the brain, is a receptor for tick-borne encephalitis virus.

Recent theory predicts that Einstein–Podolsky–Rosen arguments enable an effect in which one party can steer the other but not the converse. Researchers have now demonstrated this one-way steering effect with two entangled Gaussian modes of light, potentially opening up a new field of applications in quantum information.

Physicist who spearheaded the construction of the LIGO observatory to detect Einstein’s predicted ripples in space-time leaves a legacy of persistence and mentorship.

Heterozygous deletions in the ANKS1B gene cause ANKS1B neurodevelopmental syndrome. Here the authors show this syndrome is associated with impaired white matter integrity, and that Anks1b-deficient mouse models display deficits in oligodendrocyte maturation, myelination, and Rac1 function.

Understanding of the genetic factors and molecular mechanisms underlying neurodevelopmental disorders remains incomplete. In this study, authors show that microdeletions in the gene ANKS1B lead to loss of the neuronal synapse-enriched protein AIDA-1 and to a novel neurodevelopmental syndrome

Chemically driven blockade of PU.1 binding sites leads to its genome-wide redistribution. PU.1 network rewiring causes human acute myeloid leukemia cells to differentiate.

The immune receptor Transmembrane and immunoglobulin domain containing 2 (TMIGD2) mediates T-cell and nature killer cells co-stimulation upon B7-family HHLA2 engagement. Here, the authors show that TMIGD2 is expressed in Acute Myeloid Leukaemia stem cells regulating self-renewal and differentiation to facilitate leukemogenesis.

Macrophages have been reported to regulate thermogenic, sympathetic neuron-mediated norepinephrine signaling in adipose tissues. Here the authors report that male mice lacking the allograft inflammatory factor-1 protein are resistant to diet-induced obesity, in association with higher adipose norepinephrine levels and lower expression of the norepinephrine catabolic enzyme monoamine oxidase A.

DiNardo et al. perform a phase 1b/2 clinical trial of telaglenastat (CB-839) in combination with azacytidine in persons with advanced myelodysplastic syndromes and report on the treatment safety and efficacy, including a definition of clinical responders.

Amgalan et al. identify BAX as a therapeutic target to prevent chemotherapy-induced cardiotoxicity without affecting the antitumor properties of doxorubicin.

Single-molecule fluorescence in situ hybridization and live-cell imaging are used to study the contribution of transcriptional noise to stem cell heterogeneity, revealing that stochastic transcription dynamics are conducive to concomitant stem-cell maintenance and tissue homeostasis.

P-selectin has been considered as a biomarker of hematopoietic stem cell (HSC) aging. Here, Yang et al. uncovered a new functional role of P-selectin engagement in regulating HSC regeneration and driving stem cell aging when perturbed.

During myocardial infarction, cardiac macrophages expand, become activated and play an important role in cardiac repair and remodelling. Here the authors show that integrin α5 is upregulated in infarct macrophages and contributes to myocardial repair, triggering an angiogenic phenotype and protecting from adverse remodelling.

Individual data types in a single cell multi-omic assay are often processed and clustered independently before combined for further analysis. Here, authors showed that binarized gene expression data can be concatenated with chromatin accessibility data for effective and integrated cell clustering.

Aging, chronic high-fat diet feeding, or housing at thermoneutrality induces brown adipose tissue (BAT) involution. Here, the authors demonstrate that physiologic aging induced involution and thermogenic dysfunction result from pyroptotic signalling activation.

Resolution of G4s has been suggested to be required for efficient DNA replication. Here, the authors show that the nuclease DNA2 and the DNA repair complex MutSα (MSH2-MSH6) are required to remove G4 stabilized by environmental compounds to allow efficient telomere replication.

Deregulation of the BCL-2 family interactions ensures cancer resistance to apoptosis and is a major challenge to current treatments. Here the authors describe a novel therapeutic strategy to overcome two anti-apoptotic mechanisms for cancer therapy.

B7x is a B7-family ligand with suppressive effects on effector T cells. Here the authors show that tumor-expressed B7x promotes the conversion of conventional CD4+ T cells into regulatory T cells within the tumor microenvironment to promote immune evasion and resistance to anti-CTLA-4 therapy.

Experiments using a conditional triple-knockout mouse strain show that histone H1 regulates the activity of chromatin domains by controlling chromatin compaction, genome architecture and  histone methylation.

Intravital imaging reveals macrophage-driven de novo induction of cancer stem cells in vivo, and their dramatic enrichment on dissemination through TMEM doorways. These findings provide a mechanism for the validated ability of TMEM doorway density to be prognostic for distant recurrence of metastatic tumors in breast cancer patients.

Correlated neural variability is prominent in the visual cortex, yet its role in neural coding is debated. Here, the authors show that covariability is modulated by spatial context and that it encodes uncertainty in a probabilistic representation of natural scenes.

Using an international collection of population-based microbiome studies of participants in the MicroCardio Consortium, a cross-cohort meta-analysis identified several phylogenetically diverse, species- and strain-level microbial features as well as community-level functional shifts encompassing diverse pathways to type 2 diabetes.

A challenging problem is to identify the most central agents in interconnected multilayer networks. Here, De Domenico et al. present a mathematical framework to calculate centrality in such networks—versatility—and rank nodes accordingly.

Cui et al. identify an important role for MLL3 in regulating the hybrid epithelial–mesenchymal transition state in breast cancer and show that deletion of MLL3 enhances metastatic capacity through increased IFNγ signalling.

The intestinal stroma secretes WNT ligands but the role of WNT in intestinal repair is unclear. Here, the authors show that when WNT synthesis is ablated from stromal macrophages, the intestine morphology is normal but hypersensitive to radiation injury, implicating macrophage-derived WNT in intestinal repair.

In this whole-exome sequencing study of the largest centenarian cohort to date, Lin et al. demonstrate that conserved pathways—for example, IIS and AMPK signaling—are as relevant to human longevity and healthy aging as they are in worms, flies and mice.

Hrytsenko et al. analyze the role of obstructive sleep apnea (OSA) in diabetes mellitus (DM) risk using polygenic risk scores and mendelian randomization in a Hispanic and Latino community. Results reveal that OSA mediates the genetic risk for DM and there is a bidirectional causal relationship between OSA and DM.

Caregiving behavior is critical for infant survival. Here we show that projections from galanin neurons of medial preoptic area to perifornical area of hypothalamus are anatomically similar between males and females but have sex-specific functional roles in caregiving and stress responses.

Wang et al. show that pregnane X receptor (PXR), a well-known DNA-binding nuclear receptor, has mRNA stabilization functions when in the cytoplasm, thus unveiling a noncanonical perspective to understand and target PXR as an RNA-binding protein.