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Showing 1–29 of 29 results
Advanced filters: Author: Aled M Edwards Clear advanced filters

  • Most protein research focuses on those known before the human genome was mapped. Work on the slew discovered since, urge Aled M. Edwards and his colleagues.

    • Aled M. Edwards
    • Ruth Isserlin
    • Frank H. Yu
    Comments & Opinion
    Nature
    Volume: 470, P: 163-165

  • High-throughput chemical ligand discovery is challenged by false positives. Here, authors introduce a scalable enantioselective affinity-selection mass spectrometry approach for proteome-wide ligand discovery with high sensitivity and selectivity

    • Xiaoyun Wang
    • Jianxian Sun
    • Levon Halabelian
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-10

  • Human proteases TMPRSS2 and TMPRSS11D can be highjacked to mediate cell entry of respiratory viruses. This study examines the biochemical and structural basis of TMPRSS11D auto-activation and substrate specificity, informing peptidomimetic inhibitor development.

    • Bryan J. Fraser
    • Ryan P. Wilson
    • Cheryl H. Arrowsmith
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13

  • Target 2035 aims to develop a potent and selective pharmacological modulator for every human protein by 2035 with the results made publicly available. This Roadmap article sets out how that will be achieved.

    • Aled M. Edwards
    • Dafydd R. Owen
    • Suzanne Ackloo
    Reviews
    Nature Reviews Chemistry
    Volume: 9, P: 634-645

  • An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

    • Erola Pairo-Castineira
    • Konrad Rawlik
    • J. Kenneth Baillie
    ResearchOpen Access
    Nature
    Volume: 617, P: 764-768

  • A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

    • Mari E. K. Niemi
    • Juha Karjalainen
    • Chloe Donohue
    ResearchOpen Access
    Nature
    Volume: 600, P: 472-477

  • Protein lysine methyltransferases modulate the activities of chromatin and non-chromatin proteins by specific methylation of lysine side chains. A large-scale structure-based design approach has yielded a new chemical probe that potently and selectively inhibits G9a and GLP methyltransferases in cells.

    • Masoud Vedadi
    • Dalia Barsyte-Lovejoy
    • Jian Jin
    Research
    Nature Chemical Biology
    Volume: 7, P: 566-574

  • Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

    • Athanasios Kousathanas
    • Erola Pairo-Castineira
    • J. Kenneth Baillie
    ResearchOpen Access
    Nature
    Volume: 607, P: 97-103

  • Critical Assessment of Computational Hit-finding Experiments (CACHE) is a public benchmarking project to compare and improve computational small-molecule hit-finding approaches through cycles of prediction, compound synthesis and experimental testing. By that, CACHE will enable a more efficient and effective approach to hit identification and drug discovery.

    • Suzanne Ackloo
    • Rima Al-awar
    • Timothy M. Willson
    Reviews
    Nature Reviews Chemistry
    Volume: 6, P: 287-295

  • The Innovative Medicines Initiative Consortium RESOLUTE has started to develop tools and produce data sets to de-orphanize transporters in the solute carrier protein (SLC) superfamily, thereby lowering the barrier for the scientific community to explore SLCs as an attractive drug target class.

    • Giulio Superti-Furga
    • Daniel Lackner
    • Claire M. Steppan
    Comments & Opinion
    Nature Reviews Drug Discovery
    Volume: 19, P: 429-430

  • Chemical probes are urgently needed to functionally annotate hitherto-untargeted kinases and stimulate new drug discovery efforts to address unmet medical needs. The size of the human kinome combined with the high cost associated with probe generation severely limits access to new probes. We propose a large-scale public-private partnership as a new approach that offers economies of scale, minimized redundancy and sharing of risk and cost.

    • Stefan Knapp
    • Paulo Arruda
    • William J Zuercher
    Comments & Opinion
    Nature Chemical Biology
    Volume: 9, P: 3-6

  • The Structural Genomics Consortium (SGC) and its clinical, industry and disease-foundation partners are launching open-source preclinical translational medicine studies.

    • Aled M. Edwards
    • Cheryl H. Arrowsmith
    • L. Trevor Young
    Comments & Opinion
    Nature Reviews Drug Discovery
    Volume: 14, P: 149-150

  • We convened an ad hoc International Working Group for Antibody Validation in order to formulate the best approaches for validating antibodies used in common research applications and to provide guidelines that ensure antibody reproducibility. We recommend five conceptual 'pillars' for antibody validation to be used in an application-specific manner.

    • Mathias Uhlen
    • Anita Bandrowski
    • Tadashi Yamamoto
    Comments & Opinion
    Nature Methods
    Volume: 13, P: 823-827

  • Artificial intelligence is greatly accelerating research in drug discovery, but its development is still hindered by the lack of available data. Here the authors present data management and data science recommendations to help reach AI’s potential in the field.

    • Kristina Edfeldt
    • Aled M. Edwards
    • Matthieu Schapira
    ReviewsOpen Access
    Nature Communications
    Volume: 15, P: 1-10

  • Chemical probes are powerful reagents with increasing impacts on biomedical research. However, probes of poor quality or that are used incorrectly generate misleading results. To help address these shortcomings, we will create a community-driven wiki resource to improve quality and convey current best practice.

    • Cheryl H Arrowsmith
    • James E Audia
    • William J Zuercher
    Comments & Opinion
    Nature Chemical Biology
    Volume: 11, P: 536-541

  • YCharOS is a consensus platform for antibody characterization developed through collaboration between academia and industry, enabling direct comparisons among antibodies that target a specific protein in three common applications.

    • Riham Ayoubi
    • Joel Ryan
    • Carl Laflamme
    Protocols
    Nature Protocols
    Volume: 20, P: 1509-1545

  • A multilaboratory pilot project demonstrates that hybridoma and phage display technologies can be applied to produce high-affinity, high-specificity renewable antibodies to a set of 20 human SH2 domain proteins in a reasonable time frame, suggesting that a systematic, large-scale effort to generate renewable protein binders will be feasible.

    • Karen Colwill
    • Helena Persson
    • Susanne Gräslund
    Research
    Nature Methods
    Volume: 8, P: 551-558