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Showing 1–9 of 9 results
Advanced filters: Author: Alejo E. Rodriguez-Fraticelli Clear advanced filters

  • In this Journal Club, Alejo Rodriguez-Fratelli discusses a paper by Spudich and Koshland Jr that characterized non-genetic cell individuality in bacteria, a concept with emerging relevance to cancer progression.

    • Alejo E. Rodriguez-Fraticelli
    Research Highlights
    Nature Reviews Genetics
    Volume: 25, P: 826

  • The discovery that DNA methylation of different CpG sites can serve as digital barcodes of clonal identity led to the development of EPI-Clone, an algorithm that enables single-cell lineage tracing through cellular differentiation at scale.

    • Michael Scherer
    • Indranil Singh
    • Lars Velten
    ResearchOpen Access
    Nature
    Volume: 643, P: 478-487

  • Rettkowski, Romero-Mulero et al. show that myocardial infarction impacts bone marrow haematopoietic stem cells and leads to inflammatory myelopoiesis, which can be dampened by treatment with 4-oxo-retinoic acid, promoting cardiac recovery.

    • Jasmin Rettkowski
    • Mari Carmen Romero-Mulero
    • Nina Cabezas-Wallscheid
    ResearchOpen Access
    Nature Cell Biology
    Volume: 27, P: 591-604

  • By performing a screen for genes that regulate epithelial architecture, Martín–Belmonte and colleagues identify key roles for the synaptotagmin-like proteins Slp2-a and Slp4-a in restricting lumen generation. They find that Slp2-a targets Rab27a/b-positive vesicles to PtdIns(4,5)P2-enriched apical membranes, whereas Slp4-a controls subsequent vesicle tethering and fusion. Their coordinated activities ensure the creation of a single lumen per cell.

    • Manuel Gálvez-Santisteban
    • Alejo E. Rodriguez-Fraticelli
    • Fernando Martín-Belmonte
    Research
    Nature Cell Biology
    Volume: 14, P: 838-849

  • Immune system function declines with age, a consequence of defects in hematopoietic stem cells (HSCs). Here the authors show that TAZ buffers age-related loss of PU.1 activity to maintain HSC functionality and identify the surface protein Clca3a1 as a marker of “young-like” HSCs, even in old mice.

    • Kyung Mok Kim
    • Anna Mura-Meszaros
    • Björn von Eyss
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • Polarized-membrane trafficking supports the delivery of polarity proteins to discrete plasma-membrane domains, although the interplay between trafficking and polarity pathways is not fully understood. The small GTPases Rab8 and Rab11a direct the apical localization and activation of Cdc42 and Par3, which is essential for lumen formation.

    • David M. Bryant
    • Anirban Datta
    • Keith E. Mostov
    Research
    Nature Cell Biology
    Volume: 12, P: 1035-1045

  • Transposon tagging to clonally trace progenitors and stem cells provides evidence for a substantially revised roadmap for unperturbed haematopoiesis, and highlights unique properties of multipotent progenitors and haematopoietic stem cells in situ.

    • Alejo E. Rodriguez-Fraticelli
    • Samuel L. Wolock
    • Fernando D. Camargo
    Research
    Nature
    Volume: 553, P: 212-216