Here, the authors show that Salmonella activates the cytosolic PRR Nod-like Receptor CARD 4 (NLRC4), which limits adaptive T-cell responses in a NLRP3-dependent manner. Modification of Salmonella flagellin reduces NLRC4 activation and enhances protective immunity.
- Panagiotis Tourlomousis
- John A. Wright
- Clare E. Bryant
