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Showing 1–3 of 3 results
Advanced filters: Author: Alex Krasnitz Clear advanced filters

  • Orienting cancer drug discovery to the patient requires relating the genetic features of tumors to acquired gene and pathway dependencies and identifying small-molecule therapeutics that target them.

    • Stuart L Schreiber
    • Alykhan F Shamji
    • Bruce A Posner
    Comments & Opinion
    Nature Biotechnology
    Volume: 28, P: 904-906

  •  Malignant evolution enabled by p53 inactivation in mice proceeds through an ordered and predictable pattern of Trp53 loss of heterozygosity, accumulation of deletions, genome doubling and the emergence of gains and amplifications.

    • Timour Baslan
    • John P. Morris IV
    • Scott W. Lowe
    ResearchOpen Access
    Nature
    Volume: 608, P: 795-802

  • Although it is known that tumours are genetically heterogeneous it has so far been difficult to dissect this heterogeneity at a single cell level. This paper combines whole-genome amplification and next-generation sequencing of flow-sorted nuclei from breast tumours to investigate their population structure and evolution. In contrast to gradual models of tumour progression, the results indicate that tumours grow by punctuated clonal expansions with few persistent intermediates.

    • Nicholas Navin
    • Jude Kendall
    • Michael Wigler
    Research
    Nature
    Volume: 472, P: 90-94