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A versatile and rapid metallaphotoredox catalytic method of making ³H- and ¹¹C-labelled tracer compounds for use in positron emission tomography (PET) is reported.

Here the authors show that expanding global ancestry diversity in genomic datasets improves detection of genomic regions intolerant to variation, identifying areas more likely to harbor disease-causing mutations.

The authors demonstrate deeply subwavelength light confinement in the terahertz spectral range by exploiting the strong light–matter coupling and hyperbolicity of phonon polaritons in hafnium-based dichalcogenides.

Superconductivity is induced in an accidental Dirac semimetal via the proximity effect.

Potthoff and colleagues present a MALDI-MSI-based method that integrates in-source brightfield and fluorescence microscopy, which allows for spatially-resolved analysis of lipids and metabolites at the (sub)cellular level.

While global ocean redox patterns during the end Triassic were similar to today, pulses of localized anoxia were probably linked to mass extinctions on continental shelves, according to analysis of molybdenum records.

CCR5-deficient gamma–delta CD19 CAR T cells show resistance to HIV-mediated depletion and antitumour efficacy in B cell malignancies.

Divergent trends in biogeochemical constituents of the six largest rivers in the Arctic from 2003 to 2019 support multi-faceted changes on the Arctic landscape under global environmental change.

The Nr4a family of nuclear receptors has been implicated in thymocyte central tolerance via clonal deletion and regulatory T cell induction. Here the authors show, using mouse bone marrow chimeras, that Nr4a1 and Nr4a3 are also redundantly required for Bcl211/BIM induction and contribute to an anergy-like transcriptome in auto-reactive thymocytes.

SynGFN integrates synthesis constraints directly into the chemical design process. The result is a generative framework that produces diverse, high-quality molecules that can be readily synthesized in the laboratory.

Duan and Kaushik et al. reveal the structural basis of how Escherichia coli and Thermus thermophilus RNA polymerases initiate transcription from Np₄A alarmones producing Np₄-capped transcripts. The caps form various interactions with a polymerase during initial steps, influencing capping efficiency.

A consensus cell type atlas for the fly brain provides both an intellectual framework and open-source toolchains for brain-scale comparative connectomics.

Fouling of solid surfaces is a problem when designing microchannel systems for applications such as bioassays and drug delivery. Here Hou et al. propose a way to overcome this issue by controlling fluid flow by means of an immiscible functional liquid partly infiltrated in a porous solid matrix.

Stepwise deuteration of protonated methane CH₅⁺ — a fluxional structure that undergoes ‘hydrogen scrambling’ — leads to dramatic changes in the infrared spectra of the isotopologues. The spectra can be assigned using ab initio quantum simulations that account for the non-classical occupation — by H and D atoms — of topologically different sites within the molecule.

Electrotherapy requires electronic powered devices, set-up, and accessories. Here the authors, developed an integrated single-use platform for wearable electrotherapy as simple as a band-aid

Integrated multi-omic analyses using samples from the TRACERx study highlight cross-talk between DNA hypermethylation and genomic lesions in non-small cell lung cancer.

This work uses gene expression and single cell analyses to group extrapulmonary tuberculosis patients into three immune types, revealing immune pathways driving pathogenesis and markers that could improve diagnosis and guide tailored treatments.

Engineered DNA recombinases efficiently and specifically insert genetic cargos without the use of landing pads.

Dust preserved in Siberian ice wedges reveals shifts in wind patterns during the last glacial stage. Long-range dust transport from China to the Arctic operated under similar mechanisms as today but was blocked during the Last Glacial Maximum.

TRP channel TRPV6 is a regulator of Ca2+ homeostasis. Here, authors decipher the mechanism of TRPV6 inhibition by intracellular Mg2+ ions that bind to four sites around the intracellular pore entrance and lock the channel in the closed state.

Inorganic polyphosphates have been identified in the central nervous system. Holmström and colleagues examine neuroglial cultures in vitro and cardiorespiratory responses in vivo, and find that inorganic polyphosphates trigger calcium-dependent activation of astrocytes and increase cardiorespiratory activity.

Following on from its success in eradicating malignant B cells in cancer, chimeric antigen receptor (CAR) T cell therapy has been extended to treat autoimmune diseases. This Review discusses the preclinical studies and ongoing clinical trials of CAR T cells in autoimmune disorders, highlighting future opportunities and challenges.

Heterostructures of graphene and hexagonal boron nitride have great potential for high-mobility electronics, yet little is known about the electronic interaction between these two atomically thin materials. Here, the authors perform angle-resolved reflected-electron spectroscopy to unveil their interplay.

Magnetocaloric materials are used in adiabatic demagnetization refrigerators to reach extremely low temperature without using Helium. Here, the authors report a large magnetocaloric effect in YbPt2Sn, and show how the properties of this alloy makes it a good magnetocaloric material.

Ginhoux, Dutertre and colleagues provide a comprehensive analysis of dendritic cell subsets and states across human tumoral and juxtatumoral tissues.

A gene therapy method using AAV can help deliver HIV-fighting antibodies long-term, but the body often rejects them. Here the authors show that a short course of the drug rapamycin helps prevent host anti-drug antibody responses, showing successful antibody delivery in mice and monkeys.

Calculating electronic spectra of large systems is computationally challenging. Here, the authors combine exact short-time dynamics with approximate frequency space methods to capture narrow features embedded in a dense manifold of smaller peaks.

This study spatially maps MoS2 monolayer photoactivity, revealing static holes and mobile electrons with distinct redox zones. Bound excitons show higher efficiency, providing insights for designing advanced photocatalysts with improved performance.

ER membranes tune protein degradation to lipid composition. Using reconstitution approaches, the authors show that the ubiquitin conjugating enzyme UBE2J2 senses lipid packing, modulating its own and partner enzyme activities; together, they integrate lipid saturation and cholesterol signals.

Researchers generated 16.7 nm wavelength extreme-ultraviolet Poincaré beams at the FERMI free electron laser without relying on optical elements. The method of in situ Poincaré beam production in free electron lasers enables straightforward flexibility in the orientation and balance of polarization states, and can be extended to other vector beams and to shorter wavelengths.

Verykokakis and colleagues show that the transcription factor BCL-6 is highly expressed in stage 0 NKT and is absolutely required for innate T cell lineage development. BCL-6 acts to modify the chromatin landscape and is needed to promote the ST0–ST1 transition and PLZF expression.

A genome-wide association study including over 76,000 individuals with schizophrenia and over 243,000 control individuals identifies common variant associations at 287 genomic loci, and further fine-mapping analyses highlight the importance of genes involved in synaptic processes.

Analysis of cancer genome sequencing data has enabled the discovery of driver mutations. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium the authors present DriverPower, a software package that identifies coding and non-coding driver mutations within cancer whole genomes via consideration of mutational burden and functional impact evidence.

Two broadly reactive and inhibitory human monoclonal antibodies against the malaria parasite Plasmodium falciparum have been characterized, providing insights into immunity, prevention and treatment of severe malaria.

Analysis of the longest-lived mammal, the bowhead whale, reveals an improved ability to repair DNA breaks, mediated by high levels of cold-inducible RNA-binding protein.   

Roaming dynamics have been shown to be important in unimolecular decompositions, but the relevance to bimolecular reactions has been less clear. Here, the authors study radical addition/elimination reactions and implicate a roaming transition state in a bimolecular reaction.

Risk stratification in non-small cell lung cancer (NSCLC) remains challenging. By combining multiplex immunofluorescence, H&E histology, and AI, the study identifies spatial “cell-niche” patterns that enhance survival prediction beyond UICC8 staging. These patterns reclassify many stage I patients as high risk, revealing potentially undertreated cases and establishing spatial tumor microenvironment features as clinically actionable biomarkers.

Authors utilise a metabolomics approach to identify microbial-derived metabolites that synergistically inhibit urease activity in Proteus mirabilis, a cause of urease-induced kidney stones. They reveal that two metabolites prevented urinary catheter encrustation and improved antimicrobial efficacy against catheter biofilm.

EchoNext, a deep learning model for electrocardiograms trained and validated in diverse health systems, successfully detects many forms of structural heart disease, supporting the potential of artificial intelligence to expand access to heart disease screening at scale.

Quasi-random nanostructures are being considered for many photon management applications but their use has been limited by their costly fabrication. Here, Smith et al. show that the quasi-random patterns on Blu-ray movie discs are already near-optimized for light-trapping applications in solar cells.

CD123 expression on leukemic stem and progenitor cells (LSPCs) and leukemic blasts representing a promising therapeutic target. However previous CD123-targeting approaches had limited efficacy and safety concerns. The authors here evaluate the bispecific CD123/CD16A innate cell engager AFM28 and manifest its efficacy both in vitro and in vivo, which is mediated by NK cells.

A heat-pipe model of Earth, whereby interior heat is brought to the surface through localized channels, yields predictions that agree with craton data and the detrital zircon record, and offers a global geodynamic framework in which to explore Earth’s evolution before the onset of plate tectonics.

Covalent inhibitors that selectively target bacterial enzymes are potential antibiotic drug candidates. Here, the authors apply high-throughput screening to identify selective covalent inhibitors that target serine hydrolases in Staphylococcus aureus

Here the authors perform a trans expression quantitative trait locus meta-analysis study of over 3,700 people and link a USP18 variant to expression of 50 inflammation genes and lupus risk, highlighting how genetic regulation of immune responses drives autoimmune disease and informs new therapies.