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Ceruloplasmin gene defect associated with epilepsy in EL mice

Caroline E. Garey
Alexander L. Schwarzman
Thomas N. Seyfried
Research01 Apr 1994
Nature Genetics

Volume: 6, P: 426-431
Regulated somatic hypermutation enhances antibody affinity maturation

Germinal centre B cells modify their mutation rate to preserve high-affinity receptors, thereby safeguarding high-affinity B cell lineages and enhancing the outcomes of antibody affinity maturation.

Julia Merkenschlager
Andrew G. T. Pyo
Michel C. Nussenzweig
ResearchOpen Access19 Mar 2025
Nature

Volume: 641, P: 495-502
Mechanisms of innate and adaptive immunity to the Pfizer-BioNTech BNT162b2 vaccine

How mRNA-based coronavirus disease 2019 vaccines drive immune responses is not clear. Here the authors characterize immune responses to the BNT162b2 vaccine in mice, and show how it stimulates innate immunity, with antigen-specific CD8⁺ T cell responses dependent on the RNA sensor MDA5.

Chunfeng Li
Audrey Lee
Bali Pulendran
Research14 Mar 2022
Nature Immunology

Volume: 23, P: 543-555
Immunology: Fifty years of B lymphocytes

Alexander D. Gitlin and Michel C. Nussenzweig reflect on the discovery of two lineages of adaptive immune cells, and how it influenced vaccination, cancer therapy and the development of a class of antibody-based drugs.

Alexander D. Gitlin
Michel C. Nussenzweig
Comments & Opinion06 Jan 2015
Nature

Volume: 517, P: 139-141
Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice

Timothy LaVaute
Sophia Smith
Tracey A. Rouault
Research01 Feb 2001
Nature Genetics

Volume: 27, P: 209-214
Single-cell-resolved differentiation of human induced pluripotent stem cells into pancreatic duct-like organoids on a microwell chip

A microwell chip facilitates the single-cell characterization of the differentiation of aggregates of human induced pluripotent stem cells into pancreatic duct-like organoids and the discovery of secreted markers of pancreatic carcinogenesis.

Sandra Wiedenmann
Markus Breunig
Matthias Meier
Research08 Jul 2021
Nature Biomedical Engineering

Volume: 5, P: 897-913
Trapping and destruction of blood-borne syngeneic leukaemia cells in lung, liver and spleen of normal and leukaemic rats

T E Sadler
P Alexander
Research01 May 1976
British Journal of Cancer

Volume: 33, P: 512-520
Integration of innate immune signalling by caspase-8 cleavage of N4BP1

NEDD4-binding protein 1 (N4BP1) is identified as a suppressor of cytokine production that is inactivated by caspase-8, which provides insight into the mechanisms underlying the immunodeficiency caused by mutations in FADD and caspase-8.

Alexander D. Gitlin
Klaus Heger
Vishva M. Dixit
Research24 Sept 2020
Nature

Volume: 587, P: 275-280
Individualized, heterologous chimpanzee adenovirus and self-amplifying mRNA neoantigen vaccine for advanced metastatic solid tumors: phase 1 trial interim results

An individualized, heterologous chimpanzee adenovirus (ChAd68) and self-amplifying mRNA-based neoantigen vaccine is safe and well tolerated in patients, warranting further studies to test its potential to rescue response to checkpoint blockade in tumors of low immune reactivity.

Christine D. Palmer
Amy R. Rappaport
Karin Jooss
Research15 Aug 2022
Nature Medicine

Volume: 28, P: 1619-1629
Specifically modified Env immunogens activate B-cell precursors of broadly neutralizing HIV-1 antibodies in transgenic mice

The induction of broadly neutralizing antibodies (bNAbs) is a goal of HIV-1 vaccine research. Here the authors demonstrate the ability of an HIV Env-derived immunogen to bind germline precursors of a class of bNAbs and to activate the corresponding B cells in a knock-in mouse model

Andrew T. McGuire
Matthew D. Gray
Leonidas Stamatatos
ResearchOpen Access24 Feb 2016
Nature Communications

Volume: 7, P: 1-10
Clonal selection in the germinal centre by regulated proliferation and hypermutation

Clonal expansion and hypermutation of B cells in the germinal centre are regulated by the amount of antigen that the B cells present to follicular helper T cells.

Alexander D. Gitlin
Ziv Shulman
Michel C. Nussenzweig
Research04 May 2014
Nature

Volume: 509, P: 637-640
Sequencing and cloning of antigen-specific antibodies from mouse memory B cells

In this protocol, the variable antibody region from antigen-specific mouse memory B cells is amplified and cloned into a constant region containing vectors by a sequence/ligation-independent method and used for the production of monoclonal antibodies.

Lotta von Boehmer
Cassie Liu
Michel C Nussenzweig
Protocols15 Sept 2016
Nature Protocols

Volume: 11, P: 1908-1923

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